Extracellular vesicles in cardiovascular diseases: From pathophysiology to diagnosis and therapy

IF 9.3 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine & Growth Factor Reviews Pub Date : 2023-12-01 DOI:10.1016/j.cytogfr.2023.09.006

Yuxin Du , Lin Wu , Litao Wang , Russel J. Reiter , Gregory Y.H. Lip , Jun Ren

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Abstract

Extracellular vesicles (EVs), encompassing exosomes, microvesicles (MVs), and apoptotic bodies (ABs), are cell-derived heterogeneous nanoparticles with a pivotal role in intercellular communication. EVs are enclosed by a lipid-bilayer membrane to escape enzymatic degradation. EVs contain various functional molecules (e.g., nucleic acids, proteins, lipids and metabolites) which can be transferred from donor cells to recipient cells. EVs provide many advantages including accessibility, modifiability and easy storage, stability, biocompatibility, heterogeneity and they readily penetrate through biological barriers, making EVs ideal and promising candidates for diagnosis/prognosis biomarkers and therapeutic tools. Recently, EVs were implicated in both physiological and pathophysiological settings of cardiovascular system through regulation of cell-cell communication. Numerous studies have reported a role for EVs in the pathophysiological progression of cardiovascular diseases (CVDs) and have evaluated the utility of EVs for the diagnosis/prognosis and therapeutics of CVDs. In this review, we summarize the biology of EVs, evaluate the perceived biological function of EVs in different CVDs along with a consideration of recent progress for the application of EVs in diagnosis/prognosis and therapies of CVDs.

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心血管疾病中的细胞外小泡：从病理生理学到诊断和治疗。

细胞外小泡（EV）包括外泌体、微泡（MV）和凋亡小体（AB），是细胞衍生的异质性纳米颗粒，在细胞间通讯中发挥着关键作用。EVs被脂质双层膜包围，以逃避酶降解。EVs含有各种功能分子（如核酸、蛋白质、脂质和代谢产物），这些分子可以从供体细胞转移到受体细胞。电动汽车具有许多优点，包括可接近性、可修饰性和易储存性、稳定性、生物相容性和异质性，它们很容易穿透生物屏障，使电动汽车成为诊断/预后生物标志物和治疗工具的理想和有前途的候选者。最近，EVs通过调节细胞间通讯与心血管系统的生理和病理生理环境有关。许多研究报道了EVs在心血管疾病（CVD）病理生理进展中的作用，并评估了EVs对心血管疾病诊断/预后和治疗的效用。在这篇综述中，我们总结了EVs的生物学，评估了EVs在不同心血管疾病中的感知生物学功能，并考虑了EVs应用于心血管疾病诊断/预后和治疗的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine & Growth Factor Reviews 生物-生化与分子生物学

CiteScore

21.10

自引率

1.50%

发文量

审稿时长

22 days

期刊介绍： Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.