The TICE Pathway: Mechanisms and Potential Clinical Applications.

IF 5.7 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Current Atherosclerosis Reports Pub Date : 2023-10-01 Epub Date: 2023-09-22 DOI:10.1007/s11883-023-01147-6

Huimin Xu, Yiyang Xin, Jiaxin Wang, Zixin Liu, Yutong Cao, Weiguo Li, Yun Zhou, Yandong Wang, Peng Liu

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Abstract

Purpose of review: Transintestinal cholesterol excretion (TICE) is a non-biliary pathway that excretes excess cholesterol from the body through feces. This article focuses on the research progress of the TICE pathway in the last few years, including the discovery process of the TICE pathway, its molecular mechanism, and potential clinical applications.

Recent findings: Cholesterol homeostasis is vital for cardiovascular diseases, stroke, and neurodegenerative diseases. Beyond the cholesterol excretion via hepatobiliary pathway, TICE contributes significantly to reverse cholesterol transport ex vivo and in vivo. Nuclear receptors are ligand-activated transcription factors that regulate cholesterol metabolism. The farnesoid X receptor (FXR) and liver X receptor (LXR) activated, respectively, by oxysterols and bile acids promote intestinal cholesterol secretion through ABCG5/G8. Nutrient regulators and intestinal flora also modulate cholesterol secretion through the TICE pathway. TICE allows direct elimination of plasma cholesterol, which may provide an attractive therapeutic targets. TICE pathway may provide a potential target to stimulate cholesterol elimination and reduce the risk of cardiovascular diseases.

Abstract Image

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TICE途径：机制和潜在的临床应用。

综述目的：经肠胆固醇排泄（TICE）是一种通过粪便排出体内多余胆固醇的非胆道途径。本文重点介绍了近年来TICE途径的研究进展，包括TICE通路的发现过程、分子机制以及潜在的临床应用。最近的发现：胆固醇稳态对心血管疾病、中风和神经退行性疾病至关重要。除了通过肝胆途径排出胆固醇外，TICE还有助于逆转体内外胆固醇转运。核受体是配体激活的转录因子，调节胆固醇代谢。分别被氧化甾醇和胆汁酸激活的法尼素X受体（FXR）和肝脏X受体（LXR）通过ABCG5/G8促进肠道胆固醇分泌。营养调节剂和肠道菌群也通过TICE途径调节胆固醇分泌。TICE可以直接消除血浆胆固醇，这可能提供一个有吸引力的治疗靶点。TICE途径可能为刺激胆固醇消除和降低心血管疾病风险提供潜在的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Atherosclerosis Reports 医学-

CiteScore

9.00

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： The aim of this journal is to systematically provide expert views on current basic science and clinical advances in the field of atherosclerosis and highlight the most important developments likely to transform the field of cardiovascular prevention, diagnosis, and treatment. We accomplish this aim by appointing major authorities to serve as Section Editors who select leading experts from around the world to provide definitive reviews on key topics and papers published in the past year. We also provide supplementary reviews and commentaries from well-known figures in the field. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.