Use of Diuretics and Risk of Acute Angle Closure: A Case-Control Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-01 Epub Date: 2023-10-03 DOI:10.1080/09286586.2023.2264387

Grace L Qiao, Frederick S Mikelberg, Mahyar Etminan

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引用次数: 0

Abstract

Purpose: To examine the possible link between acute angle closure (AAC) with use of diuretics.

Methods: A nested case-control study (NCC) was conducted among a cohort of diuretic users using the PharMetrics Plus database from 2006 to 2020. Cases were identified as the first international classification of diseases 9^th and 10^th editions (ICD-9/10) code for ACC. For each case, 4 controls were selected and matched to the cases by age and sex using density-based sampling. A conditional logistic regression model was used to compute rate ratios (RRs) adjusted for the drugs topiramate, bupropion, sulphonamide antibiotics, acetazolamide, and sulfasalazine. The RRs for a negative control drug, amlodipine, was also assessed.

Results: From the initial cohort of 713 574 diuretics users, 1 553 cases and 6 212 controls were identified. No increase in the risk of AAC with current users of diuretics was found (RR = 1.06, (95% CI: 0.81-1.37) for all diuretics; RR = 0.97, (95% CI: 0.71-1.32) for thiazides; RR = 1.24, (95% CI: 0.90-1.73) for loop diuretics; RR = 0.99, (95% CI: 0.73-1.36) for potassium sparing).

Conclusion: We found no increase in the risk of acute angle closure with use of diuretics. Future studies are needed to confirm these findings.

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利尿剂的使用与急性闭角风险：一项病例对照研究。

目的：探讨急性闭角（AAC）与利尿剂使用之间的可能联系。方法：2006年至2020年，使用PharMetrics Plus数据库在利尿剂使用者队列中进行了一项嵌套病例对照研究（NCC）。病例被确定为ACC的第一个国际疾病分类第9版和第10版（ICD-9/10）代码。对于每个病例，选择4名对照，并使用基于密度的抽样按年龄和性别与病例匹配。使用条件logistic回归模型计算托吡酯、安非他酮、磺酰胺类抗生素、乙酰唑胺和柳氮磺吡啶药物的比率（RR）。阴性对照药物氨氯地平的RR也进行了评估。结果：从713 574名利尿剂使用者的初始队列中，确定了1 553例病例和6 212例对照。目前使用利尿剂的患者患AAC的风险没有增加（RR = 1.06（95%可信区间：0.81-1.37）；RR = 噻嗪类为0.97（95%可信区间：0.71-1.32）；RR = 1.24（95%CI:0.90-1.73）；RR = 0.99（95%可信区间：0.73-1.36）。结论：我们发现使用利尿剂不会增加急性闭角的风险。未来的研究需要证实这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.