Endocarditis due to Candida albicans in an immunocompromised patient: A case report

IF 1.5 4区 生物学 Q4 MYCOLOGY
José J. Flores-Patiño , Mikel J. Durán-Pacheco , Alondra M. Cázares-Marroquín , José M. Gastélum-Cano , María A. Islas-Osuna , José A. Arízaga-Berber
{"title":"Endocarditis due to Candida albicans in an immunocompromised patient: A case report","authors":"José J. Flores-Patiño ,&nbsp;Mikel J. Durán-Pacheco ,&nbsp;Alondra M. Cázares-Marroquín ,&nbsp;José M. Gastélum-Cano ,&nbsp;María A. Islas-Osuna ,&nbsp;José A. Arízaga-Berber","doi":"10.1016/j.riam.2023.06.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Fungal endocarditis is a low-frequency disease with a challenging diagnosis, as it can be mistaken with bacterial endocarditis. Fungal endocarditis causes higher mortality rates in immunocompromised patients. In the clinical practice, the endocarditis caused by fungi represents up to 10% of all infectious endocarditis cases and has a mortality rate of nearly 50%.</p></div><div><h3>Case report</h3><p>Here we present the case of a 53-year-old woman under corticosteroid therapy with a history of rheumatic heart disease, aortic valve replacement, and rheumatoid arthritis, who presented with fungal endocarditis caused by <span><em>Candida albicans</em></span>. Even though the patient received 3 years of antifungal prophylaxis with fluconazole, had valve replacement surgery, and received intensive care, the patient finally worsened and died.</p></div><div><h3>Conclusions</h3><p>Comorbidities and corticosteroid therapy predisposed the patient to acquire fungal endocarditis. This case highlights the importance of implementing procedures for the isolation and identification of fungi, and for carrying out antifungal-susceptibility testing, as well as establishing surveillance programs to identify infection-causing species and drug resistance patterns in hospitals. Moreover, designing and upgrading the algorithm for infectious endocarditis is the key to future improvements in diagnosis.</p></div>","PeriodicalId":21291,"journal":{"name":"Revista Iberoamericana De Micologia","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Iberoamericana De Micologia","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1130140623000104","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MYCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Fungal endocarditis is a low-frequency disease with a challenging diagnosis, as it can be mistaken with bacterial endocarditis. Fungal endocarditis causes higher mortality rates in immunocompromised patients. In the clinical practice, the endocarditis caused by fungi represents up to 10% of all infectious endocarditis cases and has a mortality rate of nearly 50%.

Case report

Here we present the case of a 53-year-old woman under corticosteroid therapy with a history of rheumatic heart disease, aortic valve replacement, and rheumatoid arthritis, who presented with fungal endocarditis caused by Candida albicans. Even though the patient received 3 years of antifungal prophylaxis with fluconazole, had valve replacement surgery, and received intensive care, the patient finally worsened and died.

Conclusions

Comorbidities and corticosteroid therapy predisposed the patient to acquire fungal endocarditis. This case highlights the importance of implementing procedures for the isolation and identification of fungi, and for carrying out antifungal-susceptibility testing, as well as establishing surveillance programs to identify infection-causing species and drug resistance patterns in hospitals. Moreover, designing and upgrading the algorithm for infectious endocarditis is the key to future improvements in diagnosis.

一例免疫功能低下患者因白色念珠菌引起的心内膜炎:一例报告。
背景:真菌性心内膜炎是一种低频率疾病,诊断具有挑战性,因为它可能被误认为是细菌性心内膜炎。真菌性心内膜炎导致免疫功能受损患者的死亡率较高。在临床实践中,真菌引起的心内膜炎占所有感染性心内膜炎病例的10%,死亡率接近50%。病例报告:我们报告了一名53岁的女性,她接受皮质类固醇治疗,有风湿性心脏病、主动脉瓣置换术和类风湿性关节炎病史,其表现为由白色念珠菌引起的真菌性心内膜炎。尽管患者接受了3年的氟康唑抗真菌预防治疗,进行了瓣膜置换手术,并接受了重症监护,但患者最终病情恶化并死亡。结论:合并症和皮质类固醇治疗使患者易患真菌性心内膜炎。该病例强调了实施真菌分离和鉴定程序、进行抗真菌药敏试验以及建立监测计划以确定医院中的感染致病菌种和耐药性模式的重要性。此外,设计和升级感染性心内膜炎的算法是未来改进诊断的关键。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
1.90
自引率
0.00%
发文量
17
审稿时长
81 days
期刊介绍: Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信