Comprehensive brain tissue metabolomics and biological network technology to decipher the mechanism of hydrogen-rich water on Radiation-induced cognitive impairment in rats.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2023-09-26 DOI:10.1186/s12860-023-00491-4

Xiaoming Liu, Mengya Liu, Huan Liu, Hui Yuan, Yong Wang, Xiaoman Chen, Jianguo Li, Xiujun Qin

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Abstract

Background: Hydrogen-rich water (HRW) has been shown to prevent cognitive impairment caused by ionizing radiation. This study aimed to investigate the pharmacological effects and mechanisms of HRW on ionizing radiation by coupling the brain metabolomics and biological target network methods.

Methods and results: HRW significantly improves the cognitive impairment in rats exposed to ionizing radiation. Based on metabolomics and biological network results, we identified 54 differential metabolites and 93 target genes. The KEGG pathway indicates that glutathione metabolism, ascorbic acid and aldehyde acid metabolism, pentose and glucuronic acid interconversion, and glycerophospholipid metabolism play important roles in ionizing radiation therapy.

Conclusion: Our study has systematically elucidated the molecular mechanism of HRW against ionizing radiation, which can be mediated by modulating targets, pathways and metabolite levels. This provides a new perspective for identifying the underlying pharmacological mechanism of HRW.

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综合脑组织代谢组学和生物网络技术，解读富氢水对辐射诱导的大鼠认知障碍的作用机制。

背景：富氢水（HRW）已被证明可以预防电离辐射引起的认知障碍。本研究旨在通过脑代谢组学和生物靶标网络方法相结合，探讨HRW对电离辐射的药理作用及其机制。方法与结果：HRW能显著改善电离辐射大鼠的认知功能障碍。基于代谢组学和生物网络结果，我们鉴定了54种差异代谢产物和93个靶基因。KEGG通路表明谷胱甘肽代谢、抗坏血酸和乙醛酸代谢、戊糖和葡萄糖醛酸相互转化以及甘油磷脂代谢在电离辐射治疗中发挥着重要作用。结论：我们的研究系统地阐明了HRW抗电离辐射的分子机制，该机制可以通过调节靶点、途径和代谢产物水平来介导。这为确定HRW的潜在药理学机制提供了一个新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464