Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic-Ischemic Brain Injury in Neonatal Mice.

IF 3.9 4区医学 Q2 NEUROSCIENCES

ASN NEURO Pub Date : 2023-01-01 DOI:10.1177/17590914231198983

Takuya Kawamura, Gagandeep Singh Mallah, Maryam Ardalan, Tetyana Chumak, Pernilla Svedin, Lina Jonsson, Seyedeh Marziyeh Jabbari Shiadeh, Fanny Goretta, Tomoaki Ikeda, Henrik Hagberg, Mats Sandberg, Carina Mallard

引用次数: 0

Abstract

Summary statement: Neonatal hypoxia-ischemia reduces nicotinamide adenine dinucleotide (NAD⁺) and SIRT6 levels in the injured hippocampus.Hippocampal high mobility group box-1 (HMGB1) release is significantly increased after neonatal hypoxia-ischemia.Nicotinamide mononucleotide (NMN) treatment normalizes hippocampal NAD⁺ and SIRT6 levels, with significant decrease in caspase-3 activity and HMGB1 release.NMN improves early developmental behavior, as well as motor and memory function.

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烟酰胺单核苷酸对新生小鼠缺氧缺血性脑损伤的治疗作用。

概述：新生儿缺氧缺血降低了受损海马中烟酰胺腺嘌呤二核苷酸（NAD+）和SIRT6的水平。新生儿缺氧缺血后，海马高迁移率组box-1（HMGB1）的释放显著增加。烟酰胺单核苷酸（NMN）治疗使海马NAD+和SIRT6水平正常化，胱天蛋白酶-3活性和HMGB1释放显著降低。NMN改善早期发育行为，以及运动和记忆功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ASN NEURO NEUROSCIENCES-

CiteScore

7.70

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： ASN NEURO is an open access, peer-reviewed journal uniquely positioned to provide investigators with the most recent advances across the breadth of the cellular and molecular neurosciences. The official journal of the American Society for Neurochemistry, ASN NEURO is dedicated to the promotion, support, and facilitation of communication among cellular and molecular neuroscientists of all specializations.