Nipple Lesions of the Breast: An Update on Morphologic Features, Immunohistochemical Findings and Differential Diagnosis.

IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
ACS Applied Materials & Interfaces Pub Date : 2023-11-01 Epub Date: 2023-09-26 DOI:10.1097/PAP.0000000000000413
Edi Brogi, Cristian Scatena
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引用次数: 0

Abstract

Because of the unique anatomic structure of the nipple, a few specific breast lesions occur only at this site. Large lactiferous sinuses may be involved by inflammatory conditions such as squamous metaplasia of lactiferous ducts and ductal ectasia or be the site of uncommon superficial epithelial neoplasms such as nipple adenoma or syringomatous tumor of the nipple. Paget disease of the nipple may be secondary to intraepidermal extension of ductal carcinoma in situ in the underlying lactiferous ducts or develop from malignant transformation of Toker cells. Invasive breast cancer may also arise primarily in the nipple. Most of these conditions present as a palpable mass and/or skin changes with or without nipple discharge. Due to the delicate location and often relatively small size of nipple lesions, biopsy specimens are often superficial and fragmented, and the interpretation is challenging. Knowledge of the morphologic and immunophenotypic features of nipple lesions is essential in making the correct diagnosis. Information on the molecular alterations underpinning nipple neoplasms is currently very limited.

乳腺乳头病变:形态学特征、免疫组织化学表现和鉴别诊断的最新进展。
由于乳头独特的解剖结构,少数特定的乳房病变仅发生在该部位。大的乳窦可能涉及炎症性疾病,如乳管鳞状化生和导管扩张,或者是不常见的浅表上皮肿瘤的部位,如乳头腺瘤或乳头汗腺瘤。乳头Paget病可能继发于下方乳管原位导管癌的表皮内延伸,或由Toker细胞的恶性转化发展而来。侵袭性癌症也可能主要发生在乳头。这些情况大多表现为可触摸的肿块和/或伴有或不伴有乳头分泌物的皮肤变化。由于乳头病变的位置很微妙,而且通常相对较小,活检标本往往是浅表的和碎片状的,解释起来很有挑战性。了解乳头病变的形态学和免疫表型特征对于正确诊断至关重要。关于乳头肿瘤的分子改变的信息目前非常有限。
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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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