Fatal poisoning due to aconite: Autopsy findings and postmortem quantitative analysis.

IF 1.5 4区 医学 Q2 MEDICINE, LEGAL
Forensic Science, Medicine and Pathology Pub Date : 2024-09-01 Epub Date: 2023-10-02 DOI:10.1007/s12024-023-00728-w
Huang Weisheng, Zhao Shuquan, Zhu Weiwei, Pan Meichen, Liu Huine, Dong Hongmei
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引用次数: 0

Abstract

Aconitum species are commonly used in traditional Chinese medicine, and they have a narrow therapy window due to the possibility of aconitine poisoning. Aconitine poisoning deaths appear infrequently in forensic practice. It is important to collect valuable body samples in time due to the rapid absorption and excretion of aconitine. However, it is unknown whether postmortem samples have value for toxicological analysis if the deceased has experienced long-term treatment before death. Herein, we present a case of a woman who died after 12 days of failed active treatment for aconitine poisoning. Aconitine was detected in the liver tissue. To our knowledge, this is the first case report describing the detection of aconitine in a decedent after long-term active treatment. The findings indicated that the aconitine concentration in liver tissue can be maintained after long-term treatment; this information may therefore serve as a reference in forensic practice.

Abstract Image

附子致命中毒:尸检结果和死后定量分析。
乌头属是中药中常用的物种,由于乌头碱中毒的可能性,它们的治疗窗口很窄。乌头碱中毒死亡在法医实践中很少出现。由于乌头碱的快速吸收和排泄,及时采集有价值的身体样本非常重要。然而,如果死者在死前接受过长期治疗,则尚不清楚尸检样本是否具有毒理学分析价值。在此,我们报告了一例女性在乌头碱中毒的积极治疗失败12天后死亡。在肝组织中检测到了乌头碱。据我们所知,这是第一例描述在长期积极治疗后在死者身上检测到乌头碱的病例报告。研究结果表明,经过长期治疗,肝组织中乌头碱的浓度可以维持;因此,这些信息可以作为司法实践中的参考。
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来源期刊
Forensic Science, Medicine and Pathology
Forensic Science, Medicine and Pathology MEDICINE, LEGAL-PATHOLOGY
CiteScore
3.90
自引率
5.60%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Forensic Science, Medicine and Pathology encompasses all aspects of modern day forensics, equally applying to children or adults, either living or the deceased. This includes forensic science, medicine, nursing, and pathology, as well as toxicology, human identification, mass disasters/mass war graves, profiling, imaging, policing, wound assessment, sexual assault, anthropology, archeology, forensic search, entomology, botany, biology, veterinary pathology, and DNA. Forensic Science, Medicine, and Pathology presents a balance of forensic research and reviews from around the world to reflect modern advances through peer-reviewed papers, short communications, meeting proceedings and case reports.
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