The role of oxygen in the development and treatment of bronchopulmonary dysplasia

IF 3.2 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Seminars in perinatology Pub Date : 2023-10-01 DOI:10.1016/j.semperi.2023.151814

J.X. Sotiropoulos , J.L. Oei

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引用次数: 0

Abstract

Oxygen (O₂) is crucial for both the development and treatment of one of the most important consequences of prematurity: bronchopulmonary dysplasia (BPD). In fetal life, the hypoxic environment is important for alveolar development and maturation. After birth, O₂ becomes a double-edged sword. While O₂ is needed to prevent hypoxia, it also causes oxidative stress leading to a plethora of morbidities, including retinopathy and BPD. The advent of continuous O₂ monitoring with pulse oximeters has allowed clinicians to recognize the narrow therapeutic margins of oxygenation for the preterm infant, but more knowledge is needed to understand what these ranges are at different stages of the preterm infant's life, including at birth, in the neonatal intensive care unit and after hospital discharge. Future research, especially in innovative technologies such as automated O₂ control and remote oximetry, will improve the understanding and treatment of the O₂ needs of infants with BPD.

查看原文本刊更多论文

氧气在支气管肺发育不良的发展和治疗中的作用。

氧气（O2）对早产儿最重要的后果之一：支气管肺发育不良（BPD）的发展和治疗至关重要。在胎儿生命中，缺氧环境对肺泡的发育和成熟很重要。出生后，O2就成了一把双刃剑。虽然O2是防止缺氧所必需的，但它也会导致氧化应激，导致过多的疾病，包括视网膜病变和BPD。使用脉搏血氧计进行连续O2监测的出现使临床医生能够认识到早产儿氧合的治疗范围很窄，但还需要更多的知识来了解早产儿生命的不同阶段，包括出生时、新生儿重症监护室和出院后，这些范围是什么。未来的研究，特别是在自动氧气控制和远程血氧计等创新技术方面，将提高对BPD婴儿氧气需求的理解和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in perinatology 医学-妇产科学

CiteScore

5.80

自引率

2.90%

发文量

审稿时长

6-12 weeks

期刊介绍： The purpose of each issue of Seminars in Perinatology is to provide authoritative and comprehensive reviews of a single topic of interest to professionals who care for the mother, the fetus, and the newborn. The journal''s readership includes perinatologists, obstetricians, pediatricians, epidemiologists, students in these fields, and others. Each issue offers a comprehensive review of an individual topic, with emphasis on new developments that will have a direct impact on their practice.