Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2023-10-06 DOI:10.1016/j.cbpa.2023.102401

Helena Oliveres , Marta Cascante , Joan Maurel

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Abstract

Current standard-of-care for metastatic colorectal cancer patients includes chemotherapy and anti-angiogenic or anti-epidermal growth factor receptor for microsatellite stable tumors and pembrolizumab for microsatellite instable tumors. However, despite the available therapies, the prognosis remains poor. In recent years, new drugs combined with immune checkpoint inhibitors have been tested in microsatellite stable metastatic colorectal cancer patients, but the benefit was modest. Here, we review the metabolic interactions between the immune microenvironment and cancer cells. More specifically, we highlight potential correlatives of tumor immune and metabolic features with transcriptomic classifications such as the Consensus Molecular Subtype. Finally, we discuss the unmet need of immune-metabolic signatures and the value of a new signature (IMMETCOLS) for guiding new strategies in metastatic colorectal cancer. We conclude that the field is ready to propose customized strategies for modifying metabolism and improving immunotherapy and targeted therapy efficacy.

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代谢干预提高晚期癌症的免疫疗法和靶向治疗效果。

目前转移性结直肠癌癌症患者的护理标准包括微卫星稳定肿瘤的化疗和抗血管生成或抗表皮生长因子受体，以及微卫星不稳定肿瘤的pembrolizumab。然而，尽管有可用的治疗方法，预后仍然很差。近年来，新药联合免疫检查点抑制剂已在微卫星稳定的转移性癌症患者中进行了试验，但其益处不大。在此，我们回顾了免疫微环境与癌症细胞之间的代谢相互作用。更具体地说，我们强调了肿瘤免疫和代谢特征与转录组分类（如共识分子亚型）的潜在相关性。最后，我们讨论了免疫代谢信号的未满足需求以及新信号（IMMETCOLS）在指导转移性癌症新策略方面的价值。我们的结论是，该领域已准备好提出定制的策略，以改善代谢，提高免疫疗法和靶向治疗的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.