Mechanism of Shugan Yidan fan, a Chinese herbal formula, in rat model of premature ejaculation.

IF 2.4 3区医学 Q2 ANDROLOGY

Basic and Clinical Andrology Pub Date : 2023-10-03 DOI:10.1186/s12610-023-00200-3

Qiang Han, Jun Guo, Renyuan Wang, Jiangminzi Li, Fu Wang, Qinghe Gao, Jiwei Zhang, Hetian Wang, Yin Zeng

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引用次数: 0

Abstract

Background: Premature ejaculation (PE) is one of the most common forms of sexual dysfunction in men, and multimodal therapeutic regimens should be considered to treat the condition. We developed a Chinese medicine herbal medicine, Shugan Yidan fang that had a significant clinical effect on PE patients, extending the time between penetration and ejaculation. However, the mechanism of this formula remains unclear. There is evidence that PE is associated with peripheral neuropathology, and the actions of dopamine (DA) and 5-hydroxytryptamine (5-HT). The aim of this study was to investigate the mechanism of Shugan Yidan fang's effect on PE through the relationship between sexual behavioristics and the level of neurotransmitters and dopamine receptors (DARs).

Results: We showed that the male PE groups had a significant PE phenotype compared to healthy rats. Treatment with Shugan Yidan fang improved the behavioristics of the PE rats, and reduced the expression of DAR mRNA and protein while improving dopamine transporter levels.

Conclusions: Our study provided evidence for the beneficial effect of Shugan Yidan fang in PE therapy, and proposed a preliminary potential mechanism for the clinical application of the formula.

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疏肝益胆方在早泄大鼠模型中的作用机制。

背景：早泄（PE）是男性性功能障碍最常见的形式之一，应考虑多种治疗方案来治疗这种情况。我们开发了一种中草药舒肝益胆方，它对PE患者具有显著的临床效果，延长了从渗透到射精的时间。然而，这个公式的作用机制尚不清楚。有证据表明PE与外周神经病理学以及多巴胺（DA）和5-羟色胺（5-HT）的作用有关。本研究旨在通过性行为特点与神经递质和多巴胺受体（DARs）水平的关系，探讨疏肝益胆方对PE的影响机制。结果：与健康大鼠相比，雄性PE组具有显著的PE表型。疏肝益胆方治疗改善了PE大鼠的行为学，降低了DAR mRNA和蛋白的表达，同时提高了多巴胺转运蛋白的水平。结论：本研究为疏肝益胆方在体育运动治疗中的有益作用提供了证据，并为该方的临床应用提供了初步的潜在机制。

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来源期刊

Basic and Clinical Andrology Medicine-Urology

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

22 weeks

期刊介绍： Basic and Clinical Andrology is an open access journal in the domain of andrology covering all aspects of male reproductive and sexual health in both human and animal models. The journal aims to bring to light the various clinical advancements and research developments in andrology from the international community.