Nodal properties of the resting-state brain functional network in childhood and adolescence

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging Pub Date : 2023-09-21 DOI:10.1111/jon.13155

Yu Tian, Gaoqiang Xu, Jing Zhang, Kuntao Chen, Songjiang Liu

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引用次数: 0

Abstract

Background and Purpose

Changes in the topological properties of brain functional network nodes during childhood and adolescence can provide more detailed and intuitive information on the rules of brain development. This study aims to explore the characteristics of nodal attributes in child and adolescent brain functional networks and analyze the correlation between nodal attributes in different brain regions and age.

Methods

Forty-two healthy volunteers aged 6-18 years who were right-handed primary and middle school students were recruited, and the subgroup analysis included children (6-12 years, n = 19) and adolescents (13-18 years, n = 23). Resting-state functional magnetic resonance imaging data were collected using a 3.0 Tesla MRI scanner. The topological properties of the functional brain network were analyzed using graph theory.

Results

Compared with the children group, the degree centrality and nodal efficiency of multiple brain regions in the adolescent group were significantly increased, and the nodal shortest path was reduced (q<0.05, false discovery rate corrected). These brain regions were widely distributed in the whole brain and significantly correlated with age. Compared with the children group, reduced degree centralities were observed in the left dorsolateral fusiform gyrus, left rostral cuneus gyrus, and right medial superior occipital gyrus.

Conclusion

The transmission efficiency of the brain's core network gradually increased, and the subnetwork function gradually improved in children and adolescents with age. The functional development of each brain area in the occipital visual cortex was uneven and there was functional differentiation within the occipital visual cortex.

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儿童和青少年静息状态脑功能网络的节点特性

背景与目的研究儿童和青少年时期脑功能网络节点拓扑特性的变化，可以更详细、直观地了解大脑发育规律。本研究旨在探讨儿童和青少年脑功能网络的节点属性特征，并分析不同脑区节点属性与年龄的相关性。方法招募6 ~ 18岁健康右撇子中小学生志愿者42人，亚组分析包括儿童(6 ~ 12岁，n = 19)和青少年(13 ~ 18岁，n = 23)。静息状态功能磁共振成像数据采集采用3.0 Tesla MRI扫描仪。利用图论分析了脑功能网络的拓扑性质。结果与儿童组比较，青少年组多脑区度中心性和多脑区节点效率显著提高，节点最短路径显著减少(q<0.05，错误发现率得到纠正)。这些脑区广泛分布于全脑，且与年龄显著相关。与儿童组比较，左梭状回背外侧、左喙侧楔回、右内侧枕上回的中心性程度降低。结论儿童青少年随着年龄的增长，大脑核心网络的传输效率逐渐提高，子网络功能逐渐完善。枕视皮层各脑区功能发育不均匀，且枕视皮层内部存在功能分化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!