A dual-role for IL-10: From leukemogenesis to the tumor progression in acute lymphoblastic leukemia

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2023-11-01 DOI:10.1016/j.cyto.2023.156371

Flavio Souza Silva , Amanda Barros-Lima , Mateus Souza-Barros , Juniel Assis Crespo-Neto , Vitória Giovanna Rodrigues Santos , Daniele Sá Pereira , Fabíola Silva Alves-Hanna , Fábio Magalhães-Gama , Jerusa Araújo Quintão Arantes Faria , Allyson Guimarães Costa

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Abstract

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer in the world, and accounts for 25% of all childhood cancers among children under 15 years of age. Longitudinal studies have shown that children with ALL are born with a deregulated immune response that, together with postnatal environmental exposures, favor the onset of the disease. In this context, IL-10, a key cytokine in the regulation of the immune response, presents itself as a paradoxical mediator, initially influencing the development of ALL through the regulation of inflammatory processes and later on the progression of malignancy, with the increase of this molecule in the leukemia microenvironment. According to the literature, this cytokine plays a critical role in the natural history of the disease and plays an important role in two different though complex scenarios. Thus, in this review, we explore the dual role of IL-10 in ALL, and describe its biological characteristics, immunological mechanisms and genetics, as well as its impact on the leukemia microenvironment and its clinical implications.

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IL-10的双重作用：从白血病发生到急性淋巴细胞白血病的肿瘤进展。

急性淋巴细胞白血病（ALL）是世界上最常见的儿科癌症，占15岁以下儿童癌症的25%。纵向研究表明，ALL儿童出生时免疫反应失调，再加上出生后的环境暴露，有利于疾病的发作。在这种情况下，IL-10，一种调节免疫反应的关键细胞因子，表现为一种矛盾的介质，最初通过调节炎症过程影响ALL的发展，后来随着白血病微环境中该分子的增加，影响恶性肿瘤的发展。根据文献，这种细胞因子在疾病的自然史中发挥着关键作用，并在两种不同但复杂的情况下发挥着重要作用。因此，在这篇综述中，我们探讨了IL-10在ALL中的双重作用，并描述了其生物学特性、免疫机制和遗传学，以及它对白血病微环境的影响及其临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.