[Ischemia with non-obstructive coronary artery disease: state-of-the-art review].

IF 0.7 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Giulia Ghizzoni, Luigi Di Serafino, Giulia Botti, Domenico Galante, Domenico D'Amario, Stefano Benenati, Filippo Luca Gurgoglione, Renzo Laborante, Graziella Pompei, Italo Porto, Gianluca Calogero Campo, Giampaolo Niccoli, Giovanni Esposito, Antonio Maria Leone, Alaide Chieffo
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引用次数: 0

Abstract

Chest pain affects more than 100 million people globally, however up to 70% of patients undergoing invasive angiography do not have obstructive coronary artery disease and ischemia with non-obstructive coronary artery disease (INOCA) is often a cause of the clinical picture. The symptoms reported by INOCA patients are very heterogeneous and often misdiagnosed as non-cardiac leading to under-diagnosis/investigation and under-treatment. The underlying pathophysiological mechanisms of INOCA are multiple and include coronary vasospasm and microvascular dysfunction. Most importantly, this condition must not be considered benign: compared to asymptomatic individuals, INOCA patients present an increased incidence of cardiovascular events, rehospitalizations, as well as impaired quality of life, with increasing costs for healthcare systems. The aims of this review are to describe the pathophysiological and clinical characteristics of INOCA and to provide guidance to the medical community on the diagnostic approaches and management of INOCA, also via a series of clinical case reports.

[缺血性非阻塞性冠状动脉疾病:最新进展]。
胸痛影响着全球1亿多人,然而,高达70%的接受有创血管造影术的患者没有阻塞性冠状动脉疾病,而非阻塞性冠状血管疾病(INOCA)的局部缺血通常是临床症状的原因之一。INOCA患者报告的症状非常异质,经常被误诊为非心脏性,导致诊断/调查不足和治疗不足。INOCA的潜在病理生理机制是多种多样的,包括冠状动脉血管痉挛和微血管功能障碍。最重要的是,这种情况不能被认为是良性的:与无症状个体相比,INOCA患者的心血管事件、再次住院的发生率增加,生活质量受损,医疗系统的成本增加。这篇综述的目的是描述INOCA的病理生理和临床特征,并通过一系列临床病例报告为医学界提供关于INOCA诊断方法和管理的指导。
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来源期刊
Giornale italiano di cardiologia
Giornale italiano di cardiologia CARDIAC & CARDIOVASCULAR SYSTEMS-
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