Management of nonfermenting gram-negative infections: a critique of the guidelines.

IF 3.6 3区 医学 Q2 INFECTIOUS DISEASES
Current Opinion in Infectious Diseases Pub Date : 2023-12-01 Epub Date: 2023-09-28 DOI:10.1097/QCO.0000000000000982
Matteo Bassetti, Antonio Vena, Daniele Roberto Giacobbe
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引用次数: 0

Abstract

Purpose of review: In the present narrative review, we discuss the characteristics and differences between the Infectious Diseases Society of America (IDSA) and European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines in terms on their recommendations/suggestions for the treatment of Pseudomonas aeruginosa and Acinetobacter baumannii infections.

Recent findings: Treatment of severe infections caused by nonfermenting gram-negative bacteria (NF-GNB) is posing both novel hopes and novel challenges to physicians worldwide, and both the IDSA and the ESCMID have recently updated/released their guidelines or guidance documents, based on different philosophies and providing recommendations for the treatment of NF-GNB infections. In order to correctly exploit recent advances in the treatment of such infections, IDSA and ESCMID approaches should be viewed as complementary and evolving, and should not preclude further revision based on accumulating evidence on the use of novel β-lactams and β-lactam/β-lactamase inhibitor combinations.

Summary: A joint consideration of both philosophies should leave the door opened for the wise use of novel agents, ultimately building precious experience on their use that could favorably influence future guidelines revisions.

非发酵性革兰氏阴性感染的管理:对指南的批评。
综述目的:在本叙述性综述中,我们讨论了美国传染病学会(IDSA)和欧洲临床微生物学和传染病学会指南在治疗铜绿假单胞菌和鲍曼不动杆菌感染方面的特点和差异。最近的发现:治疗由非发酵性革兰氏阴性菌(NF-GNB)引起的严重感染给世界各地的医生带来了新的希望和新的挑战,IDSA和ESCMID最近都更新/发布了基于不同理念的指南或指导文件,并为治疗NF-GNB感染提供了建议。为了正确利用治疗此类感染的最新进展,IDSA和ESCMID方法应被视为互补和发展的,不应排除在使用新型β-内酰胺和β-内胺/β-内酶抑制剂组合的积累证据的基础上进行进一步修订。总结:对这两种哲学的共同考虑应该为明智地使用新型制剂打开大门,最终积累宝贵的使用经验,从而对未来的指导方针修订产生有利影响。
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来源期刊
CiteScore
6.70
自引率
2.60%
发文量
121
审稿时长
6-12 weeks
期刊介绍: This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.
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