The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory-Zoonotic Avian Influenza and Mycobacterium tuberculosis.

IF 0.5 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Applied Biosafety Pub Date : 2023-09-01 Epub Date: 2023-09-12 DOI:10.1089/apb.2022.0038

Stuart D Blacksell, Sandhya Dhawan, Marina Kusumoto, Kim Khanh Le, Kathrin Summermatter, Joseph O'Keefe, Joseph Kozlovac, Salama Suhail Almuhairi, Indrawati Sendow, Christina M Scheel, Anthony Ahumibe, Zibusiso M Masuku, Allan M Bennett, Kazunobu Kojima, David R Harper, Keith Hamilton

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Abstract

Introduction: The Biosafety Research Road Map reviewed the scientific literature on a viral respiratory pathogen, avian influenza virus, and a bacterial respiratory pathogen, Mycobacterium tuberculosis. This project aims at identifying gaps in the data required to conduct evidence-based biorisk assessments, as described in Blacksell et al. One significant gap is the need for definitive data on M. tuberculosis sample aerosolization to guide the selection of engineering controls for diagnostic procedures.

Methods: The literature search focused on five areas: routes of inoculation/modes of transmission, infectious dose, laboratory-acquired infections, containment releases, and disinfection and decontamination methods.

Results: The available data regarding biosafety knowledge gaps and existing evidence have been collated and presented in Tables 1 and 2. The guidance sources on the appropriate use of biosafety cabinets for specific procedures with M. tuberculosis require clarification. Detecting vulnerabilities in the biorisk assessment for respiratory pathogens is essential to improve and develop laboratory biosafety in local and national systems.

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生物安全研究路线图：寻找证据支持实验室人畜共患禽流感和结核分枝杆菌的做法。

简介：生物安全研究路线图回顾了关于病毒性呼吸道病原体禽流感病毒和细菌性呼吸道病原体结核分枝杆菌的科学文献。该项目旨在确定进行循证生物风险评估所需数据的差距，如Blacksell等人所述。一个重大差距是需要结核分枝杆菌样本雾化的明确数据，以指导诊断程序的工程控制选择。方法：文献检索集中在五个领域：接种途径/传播方式、感染剂量、实验室获得性感染、控制释放以及消毒和去污方法。结果：关于生物安全知识差距的现有数据和现有证据已进行了整理，并列于表1和表2中。关于在结核分枝杆菌的特定程序中适当使用生物安全柜的指导来源需要澄清。检测呼吸道病原体生物风险评估中的漏洞对于改善和发展地方和国家系统的实验室生物安全至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Biosafety Environmental Science-Management, Monitoring, Policy and Law

CiteScore

2.50

自引率

13.30%

发文量

期刊介绍： Applied Biosafety (APB), sponsored by ABSA International, is a peer-reviewed, scientific journal committed to promoting global biosafety awareness and best practices to prevent occupational exposures and adverse environmental impacts related to biohazardous releases. APB provides a forum for exchanging sound biosafety and biosecurity initiatives by publishing original articles, review articles, letters to the editors, commentaries, and brief reviews. APB informs scientists, safety professionals, policymakers, engineers, architects, and governmental organizations. The journal is committed to publishing on topics significant in well-resourced countries as well as information relevant to underserved regions, engaging and cultivating the development of biosafety professionals globally.