Uncovering the complex role of interferon-gamma in suppressing type 2 immunity to cancer

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2023-11-01 DOI:10.1016/j.cyto.2023.156376

Asif Ahmad Bhat , Ahsas Goyal , Riya Thapa , Waleed Hassan almalki , Imran Kazmi , Sami I. Alzarea , Mahaveer Singh , Suman Rohilla , Tarun Kumar Saini , Neelima Kukreti , Dhanalekshmi Unnikrishnan Meenakshi , Neeraj Kumar Fuloria , Mahendran Sekar , Gaurav Gupta

{"title":"Uncovering the complex role of interferon-gamma in suppressing type 2 immunity to cancer","authors":"Asif Ahmad Bhat , Ahsas Goyal , Riya Thapa , Waleed Hassan almalki , Imran Kazmi , Sami I. Alzarea , Mahaveer Singh , Suman Rohilla , Tarun Kumar Saini , Neelima Kukreti , Dhanalekshmi Unnikrishnan Meenakshi , Neeraj Kumar Fuloria , Mahendran Sekar , Gaurav Gupta","doi":"10.1016/j.cyto.2023.156376","DOIUrl":null,"url":null,"abstract":"<div><p>Cancer involves cells' abnormal growth and ability to invade or metastasize to different body parts. Cancerous cells can divide uncontrollably and spread to other areas through the lymphatic or circulatory systems. Tumors form when malignant cells clump together in an uncontrolled manner. In this context, the cytokine interferon-gamma (IFN-γ) is crucial in regulating immunological responses, particularly malignancy. While IFN-γ is well-known for its potent anti-tumor effects by activating type 1 immunity, recent research has revealed its ability to suppress type 2 immunity, associated with allergy and inflammatory responses. This review aims to elucidate the intricate function of IFN-γ in inhibiting type 2 immune responses to cancer. We explore how IFN-γ influences the development and function of immune cells involved in type 2 immunity, such as mast cells, eosinophils, and T-helper 2 (Th2) cells. Additionally, we investigate the impact of IFN-mediated reduction of type 2 immunity on tumor development, metastasis, and the response to immunotherapeutic interventions. To develop successful cancer immunotherapies, it is crucial to comprehend the complex interplay between type 2 and type 1 immune response and the regulatory role of IFN-γ. This understanding holds tremendous promise for the development of innovative treatment approaches that harness the abilities of both immune response types to combat cancer. However, unraveling the intricate interplay between IFN-γ and type 2 immunity in the tumor microenvironment will be essential for achieving this goal.</p></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"171 ","pages":"Article 156376"},"PeriodicalIF":3.7000,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cytokine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1043466623002545","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 7

Abstract

Cancer involves cells' abnormal growth and ability to invade or metastasize to different body parts. Cancerous cells can divide uncontrollably and spread to other areas through the lymphatic or circulatory systems. Tumors form when malignant cells clump together in an uncontrolled manner. In this context, the cytokine interferon-gamma (IFN-γ) is crucial in regulating immunological responses, particularly malignancy. While IFN-γ is well-known for its potent anti-tumor effects by activating type 1 immunity, recent research has revealed its ability to suppress type 2 immunity, associated with allergy and inflammatory responses. This review aims to elucidate the intricate function of IFN-γ in inhibiting type 2 immune responses to cancer. We explore how IFN-γ influences the development and function of immune cells involved in type 2 immunity, such as mast cells, eosinophils, and T-helper 2 (Th2) cells. Additionally, we investigate the impact of IFN-mediated reduction of type 2 immunity on tumor development, metastasis, and the response to immunotherapeutic interventions. To develop successful cancer immunotherapies, it is crucial to comprehend the complex interplay between type 2 and type 1 immune response and the regulatory role of IFN-γ. This understanding holds tremendous promise for the development of innovative treatment approaches that harness the abilities of both immune response types to combat cancer. However, unraveling the intricate interplay between IFN-γ and type 2 immunity in the tumor microenvironment will be essential for achieving this goal.

查看原文本刊更多论文

揭示干扰素-γ在抑制癌症2型免疫中的复杂作用。

癌症涉及细胞的异常生长和入侵或转移到不同身体部位的能力。癌细胞可以不受控制地分裂，并通过淋巴或循环系统扩散到其他区域。当恶性细胞以不受控制的方式聚集在一起时，就会形成肿瘤。在这种情况下，细胞因子干扰素-γ（IFN-γ）在调节免疫反应，特别是恶性肿瘤中至关重要。虽然IFN-γ因其通过激活1型免疫而具有强大的抗肿瘤作用而闻名，但最近的研究表明，它能够抑制与过敏和炎症反应相关的2型免疫。本文旨在阐明IFN-γ在抑制癌症2型免疫应答中的复杂功能。我们探讨了IFN-γ如何影响参与2型免疫的免疫细胞的发育和功能，如肥大细胞、嗜酸性粒细胞和辅助性T细胞2（Th2）。此外，我们还研究了IFN介导的2型免疫减少对肿瘤发展、转移和免疫治疗干预反应的影响。为了开发成功的癌症免疫疗法，理解2型和1型免疫反应之间的复杂相互作用以及IFN-γ的调节作用至关重要。这一认识为开发创新的治疗方法带来了巨大的希望，这些方法利用两种免疫反应类型的能力来对抗癌症。然而，解开肿瘤微环境中IFN-γ和2型免疫之间复杂的相互作用对于实现这一目标至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.