Noninvasive evaluation of donor and native pancreases following simultaneous pancreas–kidney transplantation using positron emission tomography/computed tomography

IF 3.2 3区 医学
Takaaki Murakami, Toshihiro Nakamura, Hiroyuki Fujimoto, Junji Fujikura, Yoichi Shimizu, Kanae K. Miyake, Daisuke Otani, Kentaro Sakaki, Sakura Kiyobayashi, Takayuki Anazawa, Yuji Nakamoto, Nobuya Inagaki
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引用次数: 2

Abstract

It is crucial to develop practical and noninvasive methods to assess the functional beta-cell mass in a donor pancreas, in which monitoring and precise evaluation is challenging. A patient with type 1 diabetes underwent noninvasive imaging following simultaneous kidney–pancreas transplantation with positron emission tomography/computed tomography (PET/CT) using an exendin-based probe, [18F]FB(ePEG12)12-exendin-4. Following transplantation, PET imaging with [18F]FB(ePEG12)12-exendin-4 revealed simultaneous and distinct accumulations in the donor and native pancreases. The pancreases were outlined at a reasonable distance from the surrounding organs using [18F]FB(ePEG12)12-exendin-4 whole-body maximum intensity projection and axial PET images. At 1 and 2 h after [18F]FB(ePEG12)12-exendin-4 administration, the mean standardized uptake values were 2.96 and 3.08, respectively, in the donor pancreas and 1.97 and 2.25, respectively, in the native pancreas. [18F]FB(ePEG12)12-exendin-4 positron emission tomography imaging allowed repeatable and quantitative assessment of beta-cell mass following simultaneous kidney–pancreas transplantation.

Abstract Image

正电子发射断层扫描/计算机断层扫描对胰肾联合移植后供体和本地胰腺的无创评估
开发实用且无创的方法来评估供体胰腺中的功能性β细胞质量至关重要,在这种方法中,监测和精确评估是具有挑战性的。一名1型糖尿病患者在同时进行肾胰腺移植后,使用基于艾塞那丁的探针[18F]FB(ePEG12)12-艾塞那丁-4进行正电子发射断层扫描/计算机断层扫描(PET/CT),进行了无创成像。移植后,[18F]FB(ePEG12)12-外泌肽-4的PET成像显示供体和天然胰腺中同时存在不同的积聚。使用[18F]FB(ePEG12)12-exendin-4全身最大强度投影和轴向PET图像,在离周围器官合理距离处勾勒胰腺轮廓。在1和2 [18F]FB(ePEG12)12-外泌肽-4给药后h,供体胰腺的平均标准化摄取值分别为2.96和3.08,天然胰腺分别为1.97和2.25。[18F]FB(ePEG12)12-exendin-4正电子发射断层扫描成像允许对肾胰腺移植后的β细胞质量进行可重复的定量评估。
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来源期刊
Journal of Diabetes Investigation
Journal of Diabetes Investigation Medicine-Internal Medicine
自引率
9.40%
发文量
218
期刊介绍: Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).
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