Effect of Pre-lab Information on Chemical Spillage on Volume Subsequently Spilled: A Randomized Controlled Trial, Meta-analysis, and Comparison with Improvement through Repetition

IF 2.9 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Moray S. Stark*, Stephen A. Robertson and Aimilia M. Tsokou, 
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Abstract

Understanding methods to improve the safe handling of hazardous chemicals is important to improve laboratory safety. In this work, a simple online resource with contextual safety information on chemical spillage was developed and provided to year 1 undergraduate students prior to undertaking a laboratory practical. The effects of this safety information on amount of chemical subsequently spilled was examined using a randomized controlled trial, with a median effect size for the reduction in spillage of 37%, in comparison with those not receiving this information (95% confidence interval: −18% to 68% reduction and p = 0.14). To improve the robustness of this finding, a pretrial protocol for this randomized controlled trial was published on an open platform in a frozen document prior to data collection commencing. The effects of this pre-experiment, nonindividualized safety information was combined, using meta-analysis methodology, with results from a previous study which provided safety information postexperiment based on spillage by individual students; the effect of contextual safety information on chemical spillage gave a median reduction in spillage of 50% (95% confidence interval of 0% to 71% reduction, and p = 0.034). Any improvement through repeating the experiment was also investigated with spillage reduced by a median of 61% (95% confidence interval of 52% to 72% reduction, and p = 0.012). These three methods for reducing chemical spillage are compared using an implementation science perspective, highlighting that for the three methods discussed there is the trade-off in that the higher the evidence of benefit, the lower the ease, and hence likelihood, of implementation.

Abstract Image

实验室前化学品泄漏信息对随后泄漏量的影响:一项随机对照试验、荟萃分析以及与重复改进的比较
了解改进危险化学品安全处理的方法对于提高实验室安全性非常重要。在这项工作中,开发了一个简单的在线资源,其中包含有关化学品泄漏的上下文安全信息,并在进行实验室实践之前提供给一年级本科生。使用随机对照试验检查了该安全信息对随后泄漏的化学品量的影响,与未收到该信息的人相比,泄漏减少的中位效应大小为37%(95%置信区间:-18%-68%减少,p=0.14)。为了提高这一发现的稳健性,在数据收集开始之前,这项随机对照试验的审前方案在一个开放平台上以冷冻文件的形式发布。使用荟萃分析方法,将实验前的非个性化安全信息与先前研究的结果相结合,该研究根据个别学生的泄漏情况提供了实验后的安全信息;上下文安全信息对化学品泄漏的影响使泄漏的中位数减少了50%(95%置信区间为0%至71%,p=0.034)。通过重复实验的任何改进也被调查,泄漏的中位数降低了61%(95%置信间隔为52%至72%,p=0.012)。这三种减少化学品的方法使用实施科学的观点对溢出进行了比较,强调了所讨论的三种方法存在权衡,即效益证据越高,实施的容易性和可能性就越低。
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来源期刊
ACS Chemical Health & Safety
ACS Chemical Health & Safety PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
3.10
自引率
20.00%
发文量
63
期刊介绍: The Journal of Chemical Health and Safety focuses on news, information, and ideas relating to issues and advances in chemical health and safety. The Journal of Chemical Health and Safety covers up-to-the minute, in-depth views of safety issues ranging from OSHA and EPA regulations to the safe handling of hazardous waste, from the latest innovations in effective chemical hygiene practices to the courts'' most recent rulings on safety-related lawsuits. The Journal of Chemical Health and Safety presents real-world information that health, safety and environmental professionals and others responsible for the safety of their workplaces can put to use right away, identifying potential and developing safety concerns before they do real harm.
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