A new method for the assessment of spatial orientation and spatial anxiety in mice

Brain research. Brain research protocols Pub Date : 2004-08-01 DOI:10.1016/j.brainresprot.2004.04.003

David Rudrauf , Patrice Venault , Charles Cohen-Salmon , Alain Berthoz , Roland Jouvent , Georges Chapouthier

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引用次数: 8

Abstract

The implication of integrated functional sensory relations of the body to space in anxiety disorders is a very important issue which encourages the development of animal models, in particular, for pharmacological perspectives and for the functional assessment of the deficits induced by genetic manipulation in the mouse or the rat. A new experimental device is presented here: It is comprised of a rotating tunnel and a rotating-beam controlled by computer which can be used for multiple visuo-idiothetic and kinesthetic sensory conflict situations during active locomotor behaviour by mice. The system is linked to a digital video system, Video-Track™, designed to track and record the movements of the animals. Anxious BALB/cByJ mice were compared to non-anxious C57BL/6J mice and were seen to display highly disturbed locomotor behaviour in a sensory conflict situation. The model highlights the advantages of video-digital analysis for animal behavioural sciences.

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一种评估小鼠空间定向和空间焦虑的新方法

焦虑障碍中身体与空间的综合功能感觉关系的含义是一个非常重要的问题，它鼓励动物模型的发展，特别是在药理学角度和对小鼠或大鼠基因操作引起的缺陷的功能评估方面。本文提出了一种新的实验装置:由一个旋转通道和一个由计算机控制的旋转光束组成的实验装置，它可以用于小鼠主动运动行为中多种视觉-独特和动觉的感觉冲突情况。该系统与一个数字视频系统video - track™相连接，该系统旨在跟踪和记录动物的运动。将焦虑的BALB/cByJ小鼠与非焦虑的C57BL/6J小鼠进行比较，发现在感觉冲突情境下，BALB/cByJ小鼠表现出高度紊乱的运动行为。该模型突出了视频数字分析在动物行为科学中的优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Brain research. Brain research protocols

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