{"title":"A novel nucleic acid analogue, 3'-amino-2'-deoxy-3',4'-BNA, with an N3'-->P5' phosphoramidate linkage and an S-type conformation.","authors":"Osamu Nakagawa, Akiko Hiroto, Satoshi Obika, Takeshi Imanishi","doi":"10.1093/nass/3.1.87","DOIUrl":null,"url":null,"abstract":"<p><p>A novel bridged nucleic acid, 3'-amino-2'-deoxy-3',4'-BNA, having an N3'-->P5' phosphoramidate linkage and an S-type conformation, was successfully synthesized. It showed selective hybridization ability toward ssDNA complements, and high enzymatic stability against snake venom phosphodiesterase.</p>","PeriodicalId":86149,"journal":{"name":"Nucleic acids research. Supplement (2001)","volume":" 3","pages":"87-8"},"PeriodicalIF":0.0000,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1093/nass/3.1.87","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nucleic acids research. Supplement (2001)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/nass/3.1.87","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
A novel bridged nucleic acid, 3'-amino-2'-deoxy-3',4'-BNA, having an N3'-->P5' phosphoramidate linkage and an S-type conformation, was successfully synthesized. It showed selective hybridization ability toward ssDNA complements, and high enzymatic stability against snake venom phosphodiesterase.
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