Synthetic study of cytosaminomycins using the intramolecular glycosylation as a key step.

Hideyuki Sugimura
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引用次数: 4

Abstract

2',6'-Dideoxy-beta-D-hexopyranosyl pyrimidine nucleoside, which is a component of anticoccidal antibiotics--cytosaminomycins, was synthesized in a stereoselective manner via the intramolecular pyrimidine delivery method. Further glycosylaion of the 4'-position with a glycosyl fluoride gave the disaccharide nucleoside skeleton of the cytosaminomycins.

以分子内糖基化为关键步骤合成胞胺霉素的研究。
2',6'-二脱氧- β - d -己吡喃基嘧啶核苷是抗球虫抗生素-胞胺霉素的一种成分,通过分子内嘧啶传递法以立体选择性的方式合成。进一步用氟化糖基将4'位糖基化,形成胞胺霉素的双糖核苷骨架。
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