Characterization of trichloroacetic acid-soluble plasma protein and its variations in renal insufficiency

Abstract

• 1.

  1. Protein material in 5% trichloroacetic acid extracts of human plasma appears physically homogeneous and closely resembles α₁-acid glycoprotein (orosomucoid). Molecular weight is estimated at 41000 (±2000), E_{1%,icm²⁷⁸} is 7.7, and the protein has a high carbohydrate and sialic acid content.

• 2.

  2. Concentrations of this protein are markedly elevated in renal insufficiency.