Changes in body composition in relation to estimated glomerular filtration rate and physical activity in predialysis chronic kidney disease

Q1 Medicine

Chronic Diseases and Translational Medicine Pub Date : 2022-09-17 DOI:10.1002/cdt3.45

Prathiksha R. Bhat, Asna Urooj, Srinivas Nalloor

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引用次数: 2

Abstract

Background

Early body composition changes, associated with physical inactivity and disease advancement are devastating for patient-related outcomes in predialysis chronic kidney disease (CKD), thus warranting a detailed analysis of body composition beyond conventional measures.

Methods

The study included 40 subjects diagnosed with CKD; recruited between January to May 2021. Body composition was measured using the multifrequency analyzer, InBody 770. International Physical Activity Questionnaire-Short Form was used to assess physical activity. Suitable statistical analyses were performed using SPSS 21.0.

Results

The mean age of the subjects was 58.68 ± 12.24 years. Sarcopenic obesity was prevalent in 62.5% of the subjects. Body mass index under identified obesity by 15% compared to percent body fat, especially in subjects with low muscle mass. The decline in a unit of estimated glomerular filtration rate (eGFR) significantly correlated with a decrease in weight (p = 0.02), body fat mass (p = 0.05), visceral fat area (p = 0.05), and phase angle (p = 0.01) with marginal changes in waist–hip ratio and extracellular water/total body water. The effect of physical activity on skeletal muscle mass was homogeneous between low and moderate levels, but significantly different from high activity level.

Conclusion

Changes in fat and fluid compartment were associated with eGFR decline, whereas higher physical activity positively affected body composition.

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透析前慢性肾病患者体内成分变化与肾小球滤过率和体力活动的关系

研究背景:与缺乏运动和疾病进展相关的早期身体成分变化对透析前慢性肾脏疾病(CKD)患者相关结果具有破坏性，因此需要在常规测量之外对身体成分进行详细分析。方法纳入诊断为CKD的40例受试者;在2021年1月至5月期间招募。使用多频分析仪InBody 770测量体成分。采用国际身体活动问卷-简短表格来评估身体活动。采用SPSS 21.0进行相应的统计分析。结果患者平均年龄58.68±12.24岁。62.5%的受试者普遍存在肌肉减少性肥胖。与体脂率相比，体重指数下的肥胖率为15%，尤其是在肌肉量低的受试者中。肾小球滤过率(eGFR)单位估计值的下降与体重(p = 0.02)、体脂量(p = 0.05)、内脏脂肪面积(p = 0.05)和相位角(p = 0.01)的下降显著相关，腰臀比和细胞外水/全身水的变化较小。体力活动对骨骼肌质量的影响在低水平和中等水平之间是均匀的，但与高水平的体力活动有显著差异。结论脂肪和液体间室的变化与eGFR下降有关，而高强度的体育活动对身体成分有积极影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chronic Diseases and Translational Medicine Medicine-General Medicine

CiteScore

6.70

自引率

0.00%

发文量

195

审稿时长

35 weeks

期刊介绍： This journal aims to promote progress from basic research to clinical practice and to provide a forum for communication among basic, translational, and clinical research practitioners and physicians from all relevant disciplines. Chronic diseases such as cardiovascular diseases, cancer, diabetes, stroke, chronic respiratory diseases (such as asthma and COPD), chronic kidney diseases, and related translational research. Topics of interest for Chronic Diseases and Translational Medicine include Research and commentary on models of chronic diseases with significant implications for disease diagnosis and treatment Investigative studies of human biology with an emphasis on disease Perspectives and reviews on research topics that discuss the implications of findings from the viewpoints of basic science and clinical practic.