{"title":"Concurrent monkeypox and COVID-19: role of interleukin-1 receptor antagonist-like protein mechanism.","authors":"Rujittika Mungmunpuntipantip, Viroj Wiwanitkit","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>In 2022, monkeypox becomes a new global public health threat. Monkeypox has been present in Africa for a very long time. The COVID-19 epidemic has been affecting this region for some years. The outbreak state persists. The coexistence of the two diseases is an intriguing discovery. There is no documentation of the co-occurrence.</p><p><strong>Methods: </strong>The possibility of coexisting of the two lethal illnesses, monkeypox and COVID-19, is an intriguing scientific subject. Using bioinformatic pathophysiological pathway analysis, the authors investigated the pathophysiological pathways of COVID-19 and monkeypox.</p><p><strong>Results: </strong>The most common pathway was identified. An interleukin-1 receptor antagonist-like protein has been identified as a common pathway between the pathogenic processes of monkeypox and COVID-19.</p><p><strong>Conclusion: </strong>The findings could explain why severe COVID-19 and monkeypox do not coexist.</p>","PeriodicalId":13891,"journal":{"name":"International journal of biochemistry and molecular biology","volume":"13 5","pages":"49-53"},"PeriodicalIF":0.0000,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678746/pdf/ijbmb0013-0049.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of biochemistry and molecular biology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: In 2022, monkeypox becomes a new global public health threat. Monkeypox has been present in Africa for a very long time. The COVID-19 epidemic has been affecting this region for some years. The outbreak state persists. The coexistence of the two diseases is an intriguing discovery. There is no documentation of the co-occurrence.
Methods: The possibility of coexisting of the two lethal illnesses, monkeypox and COVID-19, is an intriguing scientific subject. Using bioinformatic pathophysiological pathway analysis, the authors investigated the pathophysiological pathways of COVID-19 and monkeypox.
Results: The most common pathway was identified. An interleukin-1 receptor antagonist-like protein has been identified as a common pathway between the pathogenic processes of monkeypox and COVID-19.
Conclusion: The findings could explain why severe COVID-19 and monkeypox do not coexist.
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