{"title":"NEK2, a promising target in TP53 mutant cancer.","authors":"Martina Cusan, Lili Wang","doi":"10.1097/BS9.0000000000000106","DOIUrl":null,"url":null,"abstract":"In human cancers, aberration of tumor suppressors and oncogenes cooperate to contribute to tumor initiation and progression.TP53, one of the best-known tumor suppressors, appears to have diverse roles through working together with different oncogenes. A good example is RAS mutations cooccurringwithTP53 lesions.KRAS hyper-activation leads to cell replicative senescence, which could be overcome by lesions in TP53, escaping immune clearance surveillance and promoting","PeriodicalId":67343,"journal":{"name":"血液科学(英文)","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/dd/41/bls-4-97.PMC9362867.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"血液科学(英文)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/BS9.0000000000000106","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/4/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
In human cancers, aberration of tumor suppressors and oncogenes cooperate to contribute to tumor initiation and progression.TP53, one of the best-known tumor suppressors, appears to have diverse roles through working together with different oncogenes. A good example is RAS mutations cooccurringwithTP53 lesions.KRAS hyper-activation leads to cell replicative senescence, which could be overcome by lesions in TP53, escaping immune clearance surveillance and promoting
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