Haploidentical transplants with a G-CSF/ATG-based protocol: Experience from China

IF 6.9 2区 医学 Q1 HEMATOLOGY
Zheng-Li Xu, Xiao-Jun Huang
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引用次数: 2

Abstract

Haploidentical donor stem cell transplantation (haplo-SCT) has made great advances in recent decades. The granulocyte colony-stimulating factor (G-CSF)- and antithymocyte globulin (ATG)-based protocol, which is known as the Beijing Protocol, represents one of the current T-cell repletion strategies in haplo-SCT. The key elements of the Beijing Protocol for graft versus host disease (GvHD) prophylaxis include G-CSF inducing T-cell tolerance and altering graft cell components, as well as ATG administration exerting an immunoregulatory effect for intensive prophylaxis. This review will summarize the GvHD incidence, the underlying novel mechanism for GvHD prophylaxis, how to optimize GvHD prophylaxis, and the recent advances of the Beijing Protocol, mainly focusing on the issues of GvHD.

基于G-CSF/ atg的单倍体移植:中国的经验
近几十年来,单倍体供体干细胞移植(haploo - sct)取得了很大的进展。基于粒细胞集落刺激因子(G-CSF)和抗胸腺细胞球蛋白(ATG)的方案被称为北京方案,代表了当前单倍体sct中t细胞补充策略之一。移植物抗宿主病(GvHD)预防北京方案的关键要素包括G-CSF诱导t细胞耐受性和改变移植物细胞成分,以及ATG给药对强化预防发挥免疫调节作用。本文将对GvHD的发病率、GvHD预防的新机制、如何优化GvHD预防以及《北京议定书》的最新进展进行综述,重点介绍GvHD的相关问题。
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来源期刊
Blood Reviews
Blood Reviews 医学-血液学
CiteScore
13.80
自引率
1.40%
发文量
78
期刊介绍: Blood Reviews, a highly regarded international journal, serves as a vital information hub, offering comprehensive evaluations of clinical practices and research insights from esteemed experts. Specially commissioned, peer-reviewed articles authored by leading researchers and practitioners ensure extensive global coverage across all sub-specialties of hematology.
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