Comparison of Placenta Previa and Placenta Accreta Spectrum Disorder Following Previous Cesarean Section between Women with a Short and Normal Interpregnancy Interval.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-08-03 eCollection Date: 2022-01-01 DOI:10.1155/2022/8028639

Uchenna Anthony Umeh, George Uchenna Eleje, Justus Uchenna Onuh, Ogochukwu Theophilus Nwankwo, Ijeoma Victoria Ezeome, Leonard Ogbonna Ajah, Ngozi Regina Dim, Samuel Nnamdi Obi, Chidebe Christian Anikwe, Joseph Ifeanyichukwu Ikechebelu

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引用次数: 1

Abstract

Objectives: The aim of this study is to determine the effect of interpregnancy interval (IPI) on the incidence of placenta previa and placenta accreta spectrum disorders in women with a previous cesarean section.

Methods: A prospective cohort three-center study involving parturients who had previous cesarean section was conducted. Participants were included if pregnancy has lasted up to 34 weeks. Parturients with co-existing uterine fibroids, multiple gestations, premature rupture of membranes, and those with prior postcesarean delivery wound infection were excluded. The eligible women recruited were distributed into two groups, namely, short (<18 months) and normal (18-36 months) IPI. The outcome measures were incidences of placenta previa and placenta accreta spectrum disorder and factors associated with the occurrence of placenta previa. A univariate analysis was performed using the chi-square test or Mann-Whitney U test, wherever appropriate, to examine the significance of the differences in clinical variables.

Results: A total of 248 women met the inclusion criteria. The incidence of placenta previa by ultrasound was 8.9% and 4.0% for short and normal IPI (odds ratios = 2.32; 95% confidence intervals = 0.78-6.88; p = 0.13), respectively. The incidence of placenta accreta spectrum disorder was 1.6% and 0.8% for short and normal IPI (odds ratios = 2.02; 95% confidence intervals = 0.18-22.13; p = 0.57), respectively. The only observed significant difference between the clinical variables and placenta previa is the number of cesarean sections (p = 0.02) in women with short IPI.

Conclusion: A short interpregnancy interval does not significantly affect the incidence of placenta previa and placenta accreta spectrum disorder following a cesarean section. There is a need for further study with large numbers to corroborate these findings in low- and middle-income settings.

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早期剖宫产后前置胎盘与增生胎盘谱系障碍的比较。

目的:本研究的目的是确定解释间隔(IPI)对既往剖宫产妇女前置胎盘和增生性胎盘谱系障碍发生率的影响。方法:采用前瞻性队列三中心研究，纳入既往剖宫产术的产妇。如果怀孕持续了34周，参与者也被包括在内。排除同时存在子宫肌瘤、多胎妊娠、胎膜早破及有剖宫产后伤口感染的产妇。招募的符合条件的妇女被分为两组，即短(U)检验，在适当的情况下，检查临床变量差异的显著性。结果:共有248名女性符合纳入标准。短IPI和正常IPI超声显示前置胎盘的发生率分别为8.9%和4.0%(优势比= 2.32;95%置信区间= 0.78-6.88;P = 0.13)。短IPI和正常IPI的胎盘增生谱系障碍发生率分别为1.6%和0.8%(优势比= 2.02;95%置信区间= 0.18-22.13;P = 0.57)。唯一观察到的临床变量与前置胎盘之间的显著差异是短IPI妇女的剖宫产次数(p = 0.02)。结论:较短的解释间隔对剖宫产术后前置胎盘和增生胎盘谱系障碍的发生率无显著影响。有必要进行进一步的大量研究，以证实低收入和中等收入环境中的这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.