Imaging features of β-catenin-activated hepatocellular adenoma with weak β-catenin activation: A rare case report.

IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Acta radiologica open Pub Date : 2022-11-23 eCollection Date: 2022-11-01 DOI:10.1177/20584601221142241
Kiyoyuki Minamiguchi, Nagaaki Marugami, Tomoko Uchiyama, Hironori Kusano, Satoshi Yasuda, Masayuki Sho, Toshihiro Tanaka
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引用次数: 1

Abstract

We report valuable imaging findings in a case of β-catenin-activated hepatocellular adenoma (β-HCA) with weak β-catenin activation. A 40 year-old female presented with a liver tumor in S8 that was incidentally detected on ultrasonography. The tumor showed marked enhancement and early venous drainage into the middle hepatic vein in the arterial phase of contrast-enhanced computed tomography (CT). The tumor revealed slight hypointensity in the hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (EOB-MRI). Six months after detection, the tumor had increased in size and a biopsy indicated hepatocellular carcinoma. The tumor was resected and pathologically diagnosed as β-HCA with weak β-catenin activation such as exon 3 S45 mutation and exon 7/8 mutation. Marked enhancement in the arterial phase of CT and MRI is a characteristic finding of β-HCA with weak β-catenin activation. Furthermore, the degree of β-catenin activation might determine the signal intensity of β-HCA in the hepatobiliary phase of EOB-MRI.

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β-连环蛋白激活的肝细胞腺瘤伴弱β-连环蛋白激活的影像学特征:1例罕见报告。
我们报告了一例β-连环蛋白激活的肝细胞腺瘤(β-HCA)与弱β-连环蛋白激活的有价值的影像学发现。一位40岁的女性在S8表现为偶然在超声检查中发现的肝脏肿瘤。造影增强CT显示肿瘤明显强化,早期静脉引流至肝中静脉。钆乙氧基苄基二乙烯三胺五乙酸增强磁共振成像(EOB-MRI)显示肿瘤肝胆期轻度低密度。检测后6个月,肿瘤体积增大,活检提示肝细胞癌。切除肿瘤,病理诊断为β-HCA,伴有β-catenin弱激活,如外显子3 S45突变和外显子7/8突变。动脉期CT和MRI明显增强是β-HCA的特征性表现,β-catenin激活弱。此外,β-catenin的活化程度可能决定了β-HCA在EOB-MRI肝胆期的信号强度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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