First report of chemical composition and cytotoxicity evaluation of Foraminispora rugosa basidiomata from Brazil.

IF 3.4 3区生物学 Q1 Agricultural and Biological Sciences

Botanical Studies Pub Date : 2022-11-26 DOI:10.1186/s40529-022-00363-8

V O Garcia, M Fronza, R Von Borowski, G Alves-Silva, A R Zimmer, T Ruaro, S C B Gnoatto, A Dallegrave, R M B Silveira

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Abstract

Background: Foraminispora rugosa is a species reported from Brazil, Venezuela, French Guiana, Costa Rica and Cuba. It is a basidiomycete in the Ganodermataceae family. In this study, both chemical composition and cytotoxicity of the ethanolic extract of F. rugosa were investigated for the first time.

Results: Phylogenetic analysis confirmed the identification of the specimens, and the results of cytotoxicity assays showed that at concentrations of 7.8-500.0 µg/mL the ethanolic extract displayed weak cytotoxicity against the tested cell lines. Five oxylipins were identified by ultra high performance liquid chromatography coupled with quadrupole time-of-flight and mass spectrometry (UHPLC-QTOF-MS).

Conclusions: This study provides new insights into the current knowledge of bioactive compounds produced by macrofungi, and provides data for future biological assays with relative selectivity and safety.

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巴西有孔孢子虫担子瘤化学成分及细胞毒性评价首次报道。

背景:rugosa有孔虫是巴西、委内瑞拉、法属圭亚那、哥斯达黎加和古巴报道的一种。它是灵芝科的担子菌。本研究首次研究了金银花乙醇提取物的化学成分和细胞毒性。结果:系统发育分析证实了标本的鉴定，细胞毒性实验结果显示，在7.8-500.0µg/mL浓度下，乙醇提取物对所测细胞系的细胞毒性较弱。采用超高效液相色谱-四极杆飞行时间-质谱联用(UHPLC-QTOF-MS)对5种氧脂类进行了鉴定。结论:本研究为目前对大型真菌产生的生物活性化合物的认识提供了新的见解，并为未来具有相对选择性和安全性的生物检测提供了数据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Botanical Studies 生物-植物科学

CiteScore

5.50

自引率

2.90%

发文量

审稿时长

2.4 months

期刊介绍： Botanical Studies is an open access journal that encompasses all aspects of botany, including but not limited to taxonomy, morphology, development, genetics, evolution, reproduction, systematics, and biodiversity of all plant groups, algae, and fungi. The journal is affiliated with the Institute of Plant and Microbial Biology, Academia Sinica, Taiwan.