Smart DNA nanogel coated polydopamine nanoparticle with high drug loading for chemo-photothermal therapy of cancer.

IF 1.6 4区医学 Q4 BIOPHYSICS

Biointerphases Pub Date : 2022-11-16 DOI:10.1116/6.0002170

Shiyu Zang, Xunxun Deng, Jiamian Wang, Yanqiu Zhao, Shuo Wu

引用次数: 2

Abstract

A smart deoxyribose nucleic acid nanogel coated polydopamine nanosphere hybrid was designed for chemo-photothermal therapy of cancer. The nanohybrid showed good colloid stability, narrow size distribution, high drug loading, good biocompatibility, and high photothermal conversion efficiency, and could release the drug on desired tumor sites.

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智能DNA纳米凝胶包被高载药量的聚多巴胺纳米颗粒用于癌症的化学光热治疗。

设计了一种智能脱氧核糖核酸纳米凝胶包被聚多巴胺纳米球复合物，用于肿瘤的化学光热治疗。该纳米杂化物具有胶体稳定性好、粒径分布窄、载药量大、生物相容性好、光热转化效率高等特点，可在肿瘤特定部位释放药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biointerphases 生物-材料科学：生物材料

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期刊介绍： Biointerphases emphasizes quantitative characterization of biomaterials and biological interfaces. As an interdisciplinary journal, a strong foundation of chemistry, physics, biology, engineering, theory, and/or modelling is incorporated into originated articles, reviews, and opinionated essays. In addition to regular submissions, the journal regularly features In Focus sections, targeted on specific topics and edited by experts in the field. Biointerphases is an international journal with excellence in scientific peer-review. Biointerphases is indexed in PubMed and the Science Citation Index (Clarivate Analytics). Accepted papers appear online immediately after proof processing and are uploaded to key citation sources daily. The journal is based on a mixed subscription and open-access model: Typically, authors can publish without any page charges but if the authors wish to publish open access, they can do so for a modest fee. Topics include: bio-surface modification nano-bio interface protein-surface interactions cell-surface interactions in vivo and in vitro systems biofilms / biofouling biosensors / biodiagnostics bio on a chip coatings interface spectroscopy biotribology / biorheology molecular recognition ambient diagnostic methods interface modelling adhesion phenomena.