[Zonulin - regulation of tight contacts in the brain and intestine - facts and hypotheses].

Q3 Biochemistry, Genetics and Molecular Biology
S N Naryzhny, O K Legina
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引用次数: 1

Abstract

In recent years, the interrelationship between the brain and the gut has become an area of high scientific interest. The intestine is responsible not only for digestion, as it contains millions of neurons, its own immune system, and affects the emotional and cognitive processes. The relationship between the gut and the brain suggests that the processes carried out by the gut microbiota play a significant role in the regulation of brain function, and vice versa. A special role here is played by intercellular tight junctions (TJ), where the zonulin protein holds an important place. Zonulin, an unprocessed precursor of mature haptoglobin, is the only physiological modulator of intercellular TJ that can reversibly regulate the permeability of the intestinal (IB) and blood-brain (BBB) barriers in the human body. BBB disruption and altered microbiota composition are associated with many diseases, including neurological disorders and neuroinflammation. That is, there is a gut-brain axis (GBA) - a communication system through which the brain modulates the functions of the gastrointestinal tract (GIT) and vice versa. GBA is based on neuronal, endocrine, and immunological mechanisms that are interconnected at the organismal, organ, cellular, and molecular levels.

[Zonulin -大脑和肠道紧密接触的调节-事实和假设]。
近年来,大脑和肠道之间的相互关系已成为一个高度科学兴趣的领域。肠道不仅负责消化,因为它包含数以百万计的神经元,它自己的免疫系统,并影响情绪和认知过程。肠道和大脑之间的关系表明,肠道微生物群所进行的过程在大脑功能的调节中起着重要作用,反之亦然。细胞间紧密连接(TJ)在这里起着特殊的作用,其中带蛋白占有重要的地位。Zonulin是一种未加工的成熟触珠蛋白前体,是细胞间TJ的唯一生理调节剂,可以可逆地调节人体肠(IB)和血脑(BBB)屏障的通透性。血脑屏障破坏和微生物群组成改变与许多疾病有关,包括神经系统疾病和神经炎症。也就是说,有一个肠脑轴(GBA)——一个大脑调节胃肠道功能(GIT)的通信系统,反之亦然。GBA基于神经元、内分泌和免疫机制,这些机制在生物体、器官、细胞和分子水平上相互联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomeditsinskaya khimiya
Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.30
自引率
0.00%
发文量
49
期刊介绍: The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).
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