Cognitive Status is Better in Older Adults under Colchicine Treatment: A Case-Control Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 Epub Date: 2022-11-14 DOI:10.1080/0361073X.2022.2145164

Arzu Okyar Baş, Gözde Kübra Yardımcı, Merve Güner Oytun, Serdar Ceylan, Zeynep Kahyaoğlu, Yelda Öztürk, Süheyla Çöteli, Meltem Gülhan Halil, Mustafa Cankurtaran, Levent Kılıç, Burcu Balam Doğu Yavuz

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引用次数: 0

Abstract

Purpose: We aimed to investigate the effects of colchicine, an important anti-inflammatory agent, on cognitive functions in a geriatric population diagnosed with gout or osteoarthritis by comparing it to non-colchicine users.

Methods: 138 geriatric patients (67 colchicine users and 71 non-users) were enrolled. Within comprehensive geriatric assessment (CGA), cognitive status assessment via Mini-Mental State Examination test (MMSE), Quick Mild Cognitive Impairment Screening test (Qmci), clock drowning test (CDT), and digit span tests were performed.

Results: Median age was 68 (65-72), and there were 82 female (59.4%) patients. The scores of CDT, Backward Digit Span Test, MMSE-Total, MMSE-Attention, MMSE-Motor Function, Qmci-Total Score, Qmci-Clock drawing, and Qmci-Logical Memory were significantly higher in the colchicine user group (p < .005), showing better cognitive function. Adjusted model analysis showed that colchicine usage is independently correlated with higher Qmci-Total Score and Qmci-Logical Memory Score (For Qmci total score β = 7.87 95%CI = 5.48-10.27, p = <0.0001, and for Qmci Logical memory score β = 3.52, 95%CI = 2.12-4.91, p = <0.0001).

Conclusion: To the best of our knowledge, this is the first study revealing that colchicine usage is associated with better cognitive performance in older adults. Further investigations with a prospective, larger-sampled and randomized design are needed to show the causal relationship between colchicine and cognition.

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接受秋水仙碱治疗的老年人认知状况更好：病例对照研究

目的：我们旨在通过与非秋水仙碱使用者的比较，研究秋水仙碱（一种重要的抗炎药物）对诊断为痛风或骨关节炎的老年患者认知功能的影响。方法：我们招募了 138 名老年患者（67 名秋水仙碱使用者和 71 名非使用者）。在老年病综合评估（CGA）中，通过小型精神状态检查测试（MMSE）、快速轻度认知功能障碍筛查测试（Qmci）、钟表溺水测试（CDT）和数字跨度测试进行了认知状态评估：中位年龄为 68 岁（65-72 岁），女性患者 82 人（59.4%）。结果：中位年龄为 68 岁（65-72 岁），82 名女性（59.4%），使用秋水仙碱的患者在 CDT、后向数字跨度测试、MMSE-总分、MMSE-注意力、MMSE-运动功能、Qmci-总分、Qmci-时钟绘图和 Qmci-逻辑记忆方面的得分均显著高于使用秋水仙碱的患者（P 结论：就我们所知，这项研究的目的是为了帮助患者更好地理解秋水仙碱：据我们所知，这是第一项揭示服用秋水仙碱与老年人认知能力提高有关的研究。要想证明秋水仙碱与认知能力之间的因果关系，还需要进行前瞻性、更大样本量和随机设计的进一步调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.