A Topical Botanical Ointment for Self-Reported Hip and/or Knee Pain: A Randomized Placebo-Controlled Clinical Trial.

IF 3.3 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE
Richard J Bloomer, Jacquelyn Pence, Roddy Morris, Michelle B Stockton, Allyson Signaigo
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Abstract

Joint pain is a common ailment among adults worldwide. Six men and 14 women (aged 51 ± 10 years) with self-reported joint pain were randomly assigned, using a cross-over design, to a botanical ointment (Yeahhh Baby!®) or placebo, twice daily for 14 days. Subjects completed questionnaires regarding their joint pain and discomfort (eg, WOMAC and subjective pain using a visual analog scale [VAS]) each evening and underwent a washout period of two weeks before crossing into the other condition. Pain and discomfort scores improved for subjects when using Yeahhh Baby!® ointment from day 1 to the average of days 2-15. For certain measures, similar, albeit insignificant, improvements were noted when subjects used the placebo-demonstrating the powerful placebo effect. Specifically, with Yeahhh Baby!® ointment, effects were noted for WOMAC pain (P = .008), WOMAC physical function (P = .024), WOMAC total (P = .019), and VAS mood interference (P = .042). The most pronounced improvement was noted for WOMAC pain (P = .048), with a 25% reduction observed with Yeahhh Baby!®, with a 10% reduction noted for placebo. These findings indicate that, as compared to a placebo, Yeahhh Baby!® ointment may provide relief to individuals suffering from joint pain in their knees and/or hips.

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局部植物药膏治疗自我报告的髋关节和/或膝关节疼痛:一项随机安慰剂对照临床试验。
关节疼痛是全世界成年人的一种常见疾病。自我报告关节疼痛的6名男性和14名女性(年龄51±10岁)随机分配,采用交叉设计,使用植物软膏(Yeahhh Baby!®)或安慰剂,每天两次,持续14天。受试者每天晚上完成关于关节疼痛和不适的问卷(例如,使用视觉模拟量表[VAS]测量WOMAC和主观疼痛),并在进入另一种情况之前进行两周的洗脱期。使用Yeahhh Baby时,受试者的疼痛和不适得分有所提高。®软膏从第1天到平均2-15天。在某些测量中,当受试者使用安慰剂时,也发现了类似的、尽管不显著的改善——这证明了强大的安慰剂效应。特别是《Yeahhh Baby!》®软膏,对WOMAC疼痛(P = 0.008)、WOMAC身体功能(P = 0.024)、WOMAC总分(P = 0.019)和VAS情绪干扰(P = 0.042)均有影响。最显著的改善是WOMAC疼痛(P = 0.048),使用Yeahhh Baby!®,安慰剂组减少了10%。这些发现表明,与安慰剂相比,耶,宝贝!®软膏可以缓解个人在膝盖和/或臀部关节疼痛。
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来源期刊
Journal of Evidence-based Integrative Medicine
Journal of Evidence-based Integrative Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
5.90
自引率
0.00%
发文量
43
审稿时长
15 weeks
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