Relationship of inflammatory mediators and sex-related parameters in Jordanian adult men patients with Covid-19.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2022-10-15 DOI:10.5937/jomb0-35601

Amneh I Al-Bashiti, Khaled A Ahmed, Khalid M Alqaisi

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引用次数: 2

Abstract

Background: Recent epidemiological data suggest that Co - ro navirus disease 2019 (COVID-19) has a gender predisposition, with men being more seriously affected than women. Furthermore, older men accounting for most deaths. Therefore, this study aimed to investigate the serum testosterone, inhibin B, intrleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a) levels in different age groups of Jordanian males with SARS-CoV2 infection and to evaluate the correlation of these markers in male patients with COVID-19.

Methods: This study was performed on 157 selected individuals divided into two groups; COVID-19 patients and healthy controls. The participants of each group were further divided into two subgroups based on the age (20-50 years and 51-80 years age groups). The biochemical tests that were performed in this research are testosterone, inhibin-B, TNF-a, and IL-6.

Results: The levels of IL-6 were significantly higher in COVID-19 patients than healthy individuals (7.63 ± 6.30 vs. 5.54 ± 2.10, P=0.006). Similarly, the difference between the levels of TNF-a in the study groups were statistically significant (P=0.001). The mean testosterone levels in COVID-19 patients and healthy controls were 1.53 ± 1.24 and 3.87 ± 1.44, respectively (P<0.001), whereas the mean inhibin B levels in COVID-19 patients (54.29 ± 7.33) were lower than in healthy controls (64.14 ± 37.66) with P = 0.011. TNF-a was significantly and positively correlated with age (r = 0.263, P=0.018) and IL-6 (r = 0.245, P=0.027). Inhibin B had a significant, but negative correlation with TNF-a (r = -0.326, P = 0.003).

Conclusions: It can be concluded that most men seeking medical attention with symptomatic COVID-19 had low testosterone and inhibin B levels with increased both IL-6 and TNF-a, which are independent of age conforming the deleterious effects of SARS-CoV-2 infection on testicular function and immune response induction.

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约旦成年男性新冠肺炎患者炎症介质与性别相关参数的关系

背景:近期流行病学数据显示，2019冠状病毒病(COVID-19)具有性别易感性，男性比女性更严重。此外，老年男子占死亡人数的大多数。因此，本研究旨在研究不同年龄段约旦男性SARS-CoV2感染患者血清睾酮、抑制素B、白细胞介素-6 (IL-6)和肿瘤坏死因子- α (TNF-a)水平，并评价这些指标与男性COVID-19患者的相关性。方法:本研究选取157例个体，分为两组;COVID-19患者和健康对照者。每组参与者根据年龄进一步分为2个亚组(20-50岁和51-80岁年龄组)。在本研究中进行的生化测试是睾酮，抑制素- b, TNF-a和IL-6。结果:新冠肺炎患者血清IL-6水平明显高于健康人群(7.63±6.30∶5.54±2.10,P=0.006)。同样，研究组中TNF-a水平的差异也有统计学意义(P=0.001)。新冠肺炎患者睾酮水平均值为1.53±1.24，健康对照组睾酮水平均值为3.87±1.44。(p)结论:有症状就诊的男性患者睾酮水平和抑制素B水平均较低，IL-6和TNF-a均升高，且与年龄无关，符合新冠肺炎感染对睾丸功能和免疫反应诱导的有害影响。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.