Antiphospholipid antibodies in healthy Serbian middle-aged subjects: Preliminary data.

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2022-10-15 DOI:10.5937/jomb0-35642

Mirjana B Bećarević, Snežana Jovičić, Svetlana D Ignjatović, Duško Mirković

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引用次数: 0

Abstract

Background: The investigation of the prevalence of the IgG and the IgM isotypes of anticardiolipin (aCL) and antib2glycoprotein I (ab2gpI) Abs in healthy Serbian middleaged subjects was the main goal of our study. In addition, we analyzed the potential associations of above-mentioned Abs with serum proteins and lipids/lipoproteins.

Methods: Forty healthy subjects were included in our study. Obesity (BMI 30 kg/m2) was present in 8/40 (20%) subjects. Titers of analyzed Abs were measured by ELISA.

Results: The prevalence of IgG and IgM ab2gpI Abs was 5% and 12.5%, respectively, while the prevalence of IgM aCL was 10%. The IgG ab2gpI Abs were significantly different between subjects with normal triglycerides levels and those with hypertriglyceridemia (Mann-Whitney, P = 0.014). The significant difference in hsCRP concentrations was observed between subjects with the increased levels of the IgM isotype of aCL Abs and those with normal IgM aCL values (Mann-Whitney, P = 0.028).

Conclusions: Dyslipidemia and BMI ≥30 were associated with aPL Abs and therefore, the correction of BMI and lipid status might be beneficial in reduction or elimination of predisposing factors that might trigger thrombotic events in otherwise healthy middle-aged subjects. Larger national study is necessary to confirm our findings.

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塞尔维亚健康中年受试者的抗磷脂抗体:初步数据

背景:调查塞尔维亚健康中年人抗心磷脂(aCL)和抗糖蛋白I (ab2gpI)抗体的IgG和IgM同型的流行情况是我们研究的主要目的。此外，我们还分析了上述抗体与血清蛋白和脂质/脂蛋白的潜在关联。方法:选取40名健康受试者。8/40(20%)受试者存在肥胖(BMI为30 kg/m2)。采用ELISA法测定抗体滴度。结果:IgG和IgM ab2gpI抗体阳性率分别为5%和12.5%，IgM aCL阳性率为10%。甘油三酯正常组与高甘油三酯血症组血清IgG ab2gpI抗体差异有统计学意义(Mann-Whitney, P = 0.014)。在aCL抗体IgM同型水平升高的受试者与IgM aCL值正常的受试者之间观察到hsCRP浓度的显著差异(Mann-Whitney, P = 0.028)。结论:血脂异常和BMI≥30与aPL抗体相关，因此，纠正BMI和脂质状态可能有助于减少或消除可能引发血栓事件的其他健康中年受试者的易感因素。需要更大规模的全国性研究来证实我们的发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.