Association of increased oncostatin M with adverse left ventricular remodeling in patients with myocardial infarction.

IF 2 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Anna M Gusakova, Tatiana E Suslova, Maria A Kercheva, Irina V Kologrivova, Tamara R Ryabova, Vyacheslav V Ryabov
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Abstract

Background: The study of laboratory biomarkers that reflect the development of adverse cardiovascular events in the postinfarction period is of current relevance. The aim of the present study was evaluation of oncostatin M (OSM) concentration changes in the early and late stages of myocardial infarction and evaluation of the possibility of its use in prediction of adverse left ventricular (LV) remodeling in patients with myocardial infarction with ST-elevated segment (STEMI).

Methods: The study involved 31 patients with STEMI admitted in the first 24 hours after the onset of MI and 30 patients with chronic coronary artery disease as a control group. Echocardiographic study was performed on day 3 and in 6 months after STEMI. The serum levels of biomarkers were evaluated on the day of hospital admission and 6 months after MI using multiplex immunoassay.

Results: OSM level increased during the first 24 h after the onset of the disease, with the following decrease in 6 months. OSM concentration at admission had correlated with echocardiography parameters and Nt-proBNP, troponin I, CK-MB levels. Our study has demonstrated association of the increased levels of OSM at the early stages of STEMI with development of the adverse LV remodeling in 6 months after the event.

Conclusions: Elevation of OSM levels in the first 24 h after STEMI is associated with the development of the adverse LV remodeling in the long-term post-infarction period.

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心肌梗死患者体内oncostatin M的增加与左心室重塑的不良影响有关。
背景:研究反映心肌梗死后不良心血管事件发展的实验室生物标志物具有现实意义。本研究的目的是评估心肌梗死早期和晚期阶段心肌抑制素 M(OSM)浓度的变化,并评估其用于预测ST段抬高型心肌梗死(STEMI)患者左心室不良重塑的可能性:研究涉及 31 名在心肌梗死发生后 24 小时内入院的 STEMI 患者和 30 名慢性冠状动脉疾病患者作为对照组。分别在 STEMI 发生后第 3 天和 6 个月进行超声心动图检查。使用多重免疫测定法对入院当天和心肌梗死后 6 个月的血清生物标志物水平进行了评估:结果:OSM水平在发病后24小时内升高,6个月后下降。入院时的 OSM 浓度与超声心动图参数、Nt-proBNP、肌钙蛋白 I 和 CK-MB 水平相关。我们的研究表明,在 STEMI 的早期阶段,OSM 水平的升高与事件发生后 6 个月左心室不良重塑的发展有关:结论:STEMI 发生后 24 小时内 OSM 水平的升高与梗死后长期左心室不良重构的发展有关。
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来源期刊
Journal of Medical Biochemistry
Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
3.00
自引率
12.00%
发文量
60
审稿时长
>12 weeks
期刊介绍: The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.
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