Sustainable Solvent-Free Diels–Alder Approaches in the Development of Constructive Heterocycles and Functionalized Materials: A Review

IF 7.1 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Topics in Current Chemistry Pub Date : 2022-08-11 DOI:10.1007/s41061-022-00398-2

Aluru Rammohan, Alexey P. Krinochkin, Albert F. Khasanov, Dmitry S. Kopchuk, Grigory V. Zyryanov

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Abstract

The Diels–Alder reaction (DAR) is found in myriad applications in organic synthesis and medicinal chemistry for drug development, as it is the method of choice for the expedient synthesis of complex natural compounds and innovative materials including nanomaterials, graphene expanses, and polymeric nanofibers. Furthermore, the greatest focus of attention of DARs is on the consistent reaction procedure with stimulus yields by highly stereo- and regioselective mechanistic pathways. Therefore, the present review is intended to summarize conventional solvent-free (SF) DARs for the expedient synthesis of heterocyclic compounds and materials. In particular, this review deals with the DARs of mechanochemical grinding, catalysis (including stereoselective catalysts), thermal, and electromagnetic radiation (such as microwave [MW], infrared [IR], and ultraviolet [UV] irradiation) in SF procedures. Therefore, this comprehensive review validates the application of DARs to pharmaceutical innovations and biorenewable materials through consistent synthetic approaches.

Graphical Abstract

Abstract Image

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可持续无溶剂Diels-Alder方法在结构杂环和功能化材料的发展:综述

Diels-Alder反应(DAR)在有机合成和药物化学开发中有着广泛的应用，因为它是合成复杂天然化合物和创新材料(包括纳米材料、石墨烯膨胀和聚合物纳米纤维)的首选方法。此外，DARs的最大关注焦点是通过高度立体和区域选择性的机制途径与刺激产量一致的反应过程。因此，本文对传统的无溶剂dar进行了综述，以方便地合成杂环化合物和材料。特别地，本文综述了机械化学研磨、催化(包括立体选择催化剂)、热辐射和电磁辐射(如微波[MW]、红外[IR]和紫外线[UV]照射)在SF过程中的dar。因此，本文通过一致的合成方法验证了dar在药物创新和生物可再生材料中的应用。图形抽象

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来源期刊

Topics in Current Chemistry Chemistry-General Chemistry

CiteScore

13.70

自引率

1.20%

发文量

期刊介绍： Topics in Current Chemistry is a journal that presents critical reviews of present and future trends in modern chemical research. It covers all areas of chemical science, including interactions with related disciplines like biology, medicine, physics, and materials science. The articles in this journal are organized into thematic collections, offering a comprehensive perspective on emerging research to non-specialist readers in academia or industry. Each review article focuses on one aspect of the topic and provides a critical survey, placing it in the context of the collection. Selected examples highlight significant developments from the past 5 to 10 years. Instead of providing an exhaustive summary or extensive data, the articles concentrate on methodological thinking. This approach allows non-specialist readers to understand the information fully and presents the potential prospects for future developments.