Effect of Medically Supervised Prolonged Fasting Therapy on Vitamin D, B12, Body Weight, Body Mass Index, Vitality and Quality of Life: A Randomized Control Trial.

IF 2.3 Q3 NUTRITION & DIETETICS

Nutrition and Metabolic Insights Pub Date : 2022-10-28 eCollection Date: 2022-01-01 DOI:10.1177/11786388221130560

Gulab Rai Tewani, Karishma Silwal, Gita Sharma, Dinesh Yadav, Aarfa Siddiqui, Sucheta Kriplani, Varsha Vijay Nathani, Neha Sharma, Jyoti Keswani, Hemanshu Sharma, Pradeep Mk Nair

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引用次数: 3

Abstract

Background: Recent research indicates prolonged fasting for more than 7 days is beneficial in priming the vitamin D metabolism. However, methodological limitations in previous studies, such as insufficient sample size and a lack of control group, limits its generalizability. The present study evaluated the impact of prolonged fasting (10 days) on vitamin D, vitamin B12, body mass index (BMI), weight, hemoglobin, vitality and quality of life (QoL) compared to a normal diet.

Methods: This randomized control trial was conducted in an in-patient private yoga and naturopathy setting between February and April 2022. A total of 52 participants (mean age 51.57 ± 13.67 years) with varying medical conditions were randomized into a fasting group (FG) or a normal diet group (NDG) with 26 participants in each group. The FG was on a fasting diet (500 kCal/day) which included holy basil herbal tea, lemon honey water, and water (3 L). The NDG (1500 kCal/day) consumed a routine diet that included Indian bread, pulses, steamed rice, vegetable salads, and beverages.

Results: The FG has shown significant increase in the Vitamin D levels (P = .003, d = 0.475), vitality (P = .006, d = 0.425), physical QoL (P < .001, d = 0.549), psychological QoL (P = .002, d = 0.488), and environmental QoL (P = .004, d = 0.457) compared to NDG. No significant changes were observed in vitamin B12, weight, BMI, haemoglobin, and social QoL. A weak to moderate (ρ = 0.330-0.483) positive correlation was observed between vitality scores and QoL domains, whereas BMI scores showed an inverse correlation (ρ = -.280) with vitamin D levels.

Conclusion: The results suggest that prolonged fasting for 10 days can improve vitamin D levels, improve vitality, and promote quality of life compared to a normal diet. Unlike previous studies, the FG does not differ from the NDG concerning weight and BMI. Nevertheless, fasting may be utilized as an effective tool to tackle vitamin D deficiency and associated health insufficiencies.

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医学监督下延长禁食治疗对维生素D、B12、体重、体重指数、活力和生活质量的影响:一项随机对照试验

背景:最近的研究表明，长时间禁食超过7天有利于启动维生素D的代谢。然而，以往研究的方法局限性，如样本量不足和缺乏对照组，限制了其普遍性。本研究评估了与正常饮食相比，长时间禁食(10天)对维生素D、维生素B12、体重指数(BMI)、体重、血红蛋白、活力和生活质量(QoL)的影响。方法:这项随机对照试验于2022年2月至4月在一家私人瑜伽和自然疗法的住院患者中进行。52例不同医疗条件的参与者(平均年龄51.57±13.67岁)被随机分为禁食组(FG)和正常饮食组(NDG)，每组26例。受试者禁食(500千卡/天)，包括圣罗勒花草茶、柠檬蜂蜜水和水(3升)。NDG(1500千卡/天)的日常饮食包括印度面包、豆类、米饭、蔬菜沙拉和饮料。结果:FG显示维生素D水平显著升高(P =。003, d = 0.475)，活力(P =。006, d = 0.425)，生理生活质量(P d = 0.549)，心理生活质量(P = 0.549)。002, d = 0.488)，环境生活质量(P =。004, d = 0.457)。在维生素B12、体重、BMI、血红蛋白和社会生活质量方面没有观察到明显的变化。活力评分与生活质量域之间呈弱至中度正相关(ρ = 0.330-0.483)，而BMI评分与维生素D水平呈负相关(ρ = - 0.280)。结论:结果表明，与正常饮食相比，延长禁食10天可以提高维生素D水平，增强活力，提高生活质量。与以往的研究不同，FG与NDG在体重和BMI方面没有差异。然而，禁食可以作为一种有效的工具来解决维生素D缺乏和相关的健康问题。

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来源期刊

Nutrition and Metabolic Insights NUTRITION & DIETETICS-

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focusing on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels. This journal welcomes new manuscripts for peer review on the following topics: Nutrition, including the biochemistry of metabolism, Exercise and associated physical processes, Clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes, Research at the molecular, cellular and organismal levels, Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.