Mortality of intubated patients with COVID-19 during first and subsequent waves: a meta-analysis involving 363,660 patients from 43 countries.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2022-10-01 Epub Date: 2022-11-17 DOI:10.1080/17476348.2022.2145950

Eleni Xourgia, Dimitrios E Katsaros, Nikoleta A Xixi, Vasiliki Tsolaki, Christina Routsi, Spyros G Zakynthinos, Anastasia Kotanidou, Ilias I Siempos

{"title":"Mortality of intubated patients with COVID-19 during first and subsequent waves: a meta-analysis involving 363,660 patients from 43 countries.","authors":"Eleni Xourgia, Dimitrios E Katsaros, Nikoleta A Xixi, Vasiliki Tsolaki, Christina Routsi, Spyros G Zakynthinos, Anastasia Kotanidou, Ilias I Siempos","doi":"10.1080/17476348.2022.2145950","DOIUrl":null,"url":null,"abstract":"Background: We attempted to investigate the change in mortality of intubated patients with coronavirus disease (COVID-19) from first to subsequent waves across several countries.Methods: We pre-registered our meta-analysis with PROSPERO [Anonymized]. We searched PubMed, Scopus, and gray literature for observational studies reporting data on all-cause mortality of intubated patients with COVID-19 recruited both during first and subsequent waves of the pandemic. We considered studies published after 31 August 2020 up to 12 July 2021. The primary outcome of the meta-analysis was all-cause mortality. We used a random effects model to calculate pooled risk ratio (RR) and 95% confidence intervals (CI).Results: By incorporating data of 363,660 patients from 43 countries included in 28 studies, we found that all-cause mortality of intubated patients with COVID-19 increased from first to subsequent waves (from 62.2% to 72.6%; RR 0.90, 95% CI 0.85-0.94, p < 0.00001). This finding was independent of the geo-economic variation of the included studies and persisted in several pre-specified subgroup and sensitivity analyses.Conclusions: The robust finding of this meta-analysis suggests that mortality of intubated patients with COVID-19 did not improve over time. Future research should target this group of patients to further optimize their management.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"1101-1108"},"PeriodicalIF":4.6000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17476348.2022.2145950","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/11/17 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 2

Abstract

Background: We attempted to investigate the change in mortality of intubated patients with coronavirus disease (COVID-19) from first to subsequent waves across several countries.

Methods: We pre-registered our meta-analysis with PROSPERO [Anonymized]. We searched PubMed, Scopus, and gray literature for observational studies reporting data on all-cause mortality of intubated patients with COVID-19 recruited both during first and subsequent waves of the pandemic. We considered studies published after 31 August 2020 up to 12 July 2021. The primary outcome of the meta-analysis was all-cause mortality. We used a random effects model to calculate pooled risk ratio (RR) and 95% confidence intervals (CI).

Results: By incorporating data of 363,660 patients from 43 countries included in 28 studies, we found that all-cause mortality of intubated patients with COVID-19 increased from first to subsequent waves (from 62.2% to 72.6%; RR 0.90, 95% CI 0.85-0.94, p < 0.00001). This finding was independent of the geo-economic variation of the included studies and persisted in several pre-specified subgroup and sensitivity analyses.

Conclusions: The robust finding of this meta-analysis suggests that mortality of intubated patients with COVID-19 did not improve over time. Future research should target this group of patients to further optimize their management.

查看原文本刊更多论文

第一波和随后的COVID-19插管患者死亡率:一项涉及43个国家363,660名患者的荟萃分析。

背景:我们试图调查几个国家的冠状病毒病(COVID-19)插管患者从第一波到随后的死亡率变化。方法:我们在PROSPERO[匿名]预先注册了meta分析。我们检索了PubMed、Scopus和灰色文献，寻找报告在大流行的第一波和随后的浪潮中招募的COVID-19插管患者全因死亡率数据的观察性研究。我们考虑了2020年8月31日至2021年7月12日期间发表的研究。荟萃分析的主要结果是全因死亡率。我们使用随机效应模型计算合并风险比(RR)和95%置信区间(CI)。结果:通过纳入28项研究中来自43个国家的363,660例患者的数据，我们发现COVID-19插管患者的全因死亡率从第一波增加到随后的波(从62.2%增加到72.6%;RR 0.90, 95% CI 0.85-0.94, p < 0.00001)。这一发现独立于纳入研究的地理经济差异，并在几个预先指定的亚组和敏感性分析中持续存在。结论:这项荟萃分析的有力发现表明，COVID-19插管患者的死亡率并没有随着时间的推移而改善。未来的研究应针对这组患者进一步优化其管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.