Sex differences in normal and malignant hematopoiesis.

IF 1.5 Q3 HEMATOLOGY
血液科学(英文) Pub Date : 2022-10-01 Epub Date: 2022-08-16 DOI:10.1097/BS9.0000000000000133
Xiaojing Cui, Xinghui Zhao, Ying Liang
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引用次数: 5

Abstract

Hematopoiesis is a continuous and well-regulated process requiring both the capacity for self-renewal and the potential for differentiation of hematopoietic stem cells. Multiple studies indicate that sex hormones exert significant effects on not only hematopoietic stem and progenitor cells, but also the development of hematopoietic lineages, resulting in sexual dimorphisms in normal hematopoiesis. Hematologic malignancies comprise a wide variety of cancers affecting the blood, bone marrow, and lymphatic system, such as leukemia, lymphoma, myeloma, myelodysplastic syndrome, and myeloproliferative diseases. Overall, males are at greater risk and have worse prognosis for most of these malignancies compared with females. A better understanding of the differences between male and female could be of substantial value in research as well as clinical management.

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正常和恶性造血的性别差异。
造血是一个持续的、调控良好的过程,既需要造血干细胞自我更新的能力,也需要造血干细胞分化的潜力。多项研究表明,性激素不仅对造血干细胞和祖细胞有显著影响,而且对造血世系的发育也有显著影响,导致正常造血过程中出现性别二型现象。血液恶性肿瘤包括影响血液、骨髓和淋巴系统的各种各样的癌症,如白血病、淋巴瘤、骨髓瘤、骨髓增生异常综合征和骨髓增生性疾病。总的来说,与女性相比,男性患这些恶性肿瘤的风险更大,预后也更差。更好地了解男性和女性之间的差异可能在研究和临床管理中具有重大价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.70
自引率
0.00%
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审稿时长
10 weeks
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