Cerebellar Gray Matter Volume and its Role in Executive Function, and Attention: Sex Differences by Age in Adolescents.

IF 2.4 4区医学 Q3 NEUROSCIENCES

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-11-30 DOI:10.9758/cpn.2022.20.4.621

Hayeon Kim, Bumhee Park, Shin-Young Kim, Jiyea Kim, Bora Kim, Kyu-In Jung, Seung-Yup Lee, Yerin Hyun, Bung-Nyun Kim, Subin Park, Min-Hyeon Park

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引用次数: 1

Abstract

Objective: This research measures the regional GMV (rGMV) of the cerebellum, attention, Executive Function (EF) and we aimed to identify their correlation and sex differences in children and adolescents.

Methods: Subjects comprised 114 children (male = 62, female = 52, 12.44 ± 2.99 years old) from South Korea. Participants were divided into three groups by age (age 6-9, 10-13, and 14-17). The Stroop Color and Word Test (SCWT), Wisconsin Card Sorting Test (WCST), and Advanced Test of Attention (ATA) were used to estimate executive function. Magnetic resonance imaging (MRI) images were analyzed with Regional Voxel-Based Morphometry Analysis.

Results: The correlations between cerebellar rGMV and SCWT, WCST, and ATA subcategories showed difference by age and sex. In 6-9 age group, girls showed more overall correlations with cerebellar regions than boys, in WCST Categories Completed and ATA results. In age 10-13 group, more regions of cerebellum corresponded to SCWT subcategories in girls. Nevertheless, more correlation between cerebellar rGMV, WCST subcategories and some ATA subtests were observed in boys in the same age group. In the adolescent group, aged 14-17, boys showed more correlation with cerebellar rGMV, while girls showed little correlation.

Conclusion: This study highlights that sex-different cerebellum maturation in adolescence might be correlated with EF and attention. These results provides evidence that cerebellum modulates higher cognitive functioning during child development.

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小脑灰质体积及其在执行功能和注意力中的作用:青少年年龄的性别差异。

目的:研究儿童和青少年小脑、注意、执行功能(EF)的区域GMV (rGMV)，探讨其相关性和性别差异。方法:选取韩国儿童114例(男62例，女52例，年龄12.44±2.99岁)。参与者按年龄分为三组(6-9岁、10-13岁和14-17岁)。使用Stroop Color and Word Test (SCWT)、Wisconsin Card Sorting Test (WCST)和Advanced Test of Attention (ATA)来评估执行功能。磁共振成像(MRI)图像采用基于区域体素的形态分析方法进行分析。结果:小脑rGMV与SCWT、WCST、ATA亚型的相关性存在年龄、性别差异。在6-9岁年龄组中，在WCST分类完成和ATA结果中，女孩与小脑区域的整体相关性高于男孩。在10-13岁年龄组中，女孩的小脑区域与SCWT亚类别相对应。然而，在同一年龄组的男孩中，观察到小脑rGMV、WCST亚类别和一些ATA亚测试之间的相关性更强。在14-17岁的青少年组中，男孩与小脑rGMV的相关性更强，而女孩的相关性较小。结论:本研究提示性别差异的青春期小脑成熟可能与EF和注意力相关。这些结果提供了小脑在儿童发育过程中调节高级认知功能的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Psychopharmacology and Neuroscience NEUROSCIENCESPHARMACOLOGY & PHARMACY-PHARMACOLOGY & PHARMACY

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： Clinical Psychopharmacology and Neuroscience (Clin Psychopharmacol Neurosci) launched in 2003, is the official journal of The Korean College of Neuropsychopharmacology (KCNP), and the associate journal for Asian College of Neuropsychopharmacology (AsCNP). This journal aims to publish evidence-based, scientifically written articles related to clinical and preclinical studies in the field of psychopharmacology and neuroscience. This journal intends to foster and encourage communications between psychiatrist, neuroscientist and all related experts in Asia as well as worldwide. It is published four times a year at the last day of February, May, August, and November.