Candidemia: Changing dynamics from a tertiary care hospital in North India.

Q3 Medicine
Garima Gautam, Deepti Rawat, Ravinder Kaur, Masoom Nathani
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引用次数: 4

Abstract

Background and purpose: Routine identification of Candida species and knowledge of antibiotic susceptibility patterns can prevent diagnostic delays and help clinicians choose appropriate empirical therapies. This study aimed to identify and speciate Candida isolates from bloodstream infections and evaluate their epidemiological profile and antibiotic susceptibility pattern in a tertiary care hospital in North India.

Materials and methods: Blood samples were cultured in the Department of Microbiology of a tertiary care hospital from January 2019 to May 2021, and the samples which showed growth of Candida species (spp.) were included in this study. Candida isolates were initially characterized by conventional techniques. Further identification and antifungal susceptibility testing were performed using Vitek 2 compact automated system. Data analysis was performed using the SPSS software (Version 25.0).

Results: Candida spp. were isolated from a total of 116 blood samples, 60.92% of which belonged to males. The majority (43.10%) of isolates were obtained from 0-1-month-old neonates, followed by infants (16.38%) and children in the age range of 1-17 years (16.38%). Only 6.89% of isolates were obtained from adults older than 18 years. Candida tropicalis (26.72%) was the most common species, followed by Candida pelliculosa (19.83%), Candida albicans (17.24%), Candida parapsilosis (14.66%), Candida famata (9.48%), and Candida krusei (9.48%). Other isolated species included Candida lusitaniae, Candida sphaerica, and Candida inconspicua. Out of 116 isolates, 101 isolates were subjected to Vitek 2 susceptibility testing. Overall, 21.78% (22/101) of Candida isolates were found to be resistant/intermediate. Among C. albicans isolates, resistance was observed only against voriconazole (20%) and fluconazole (5%); however, among non- albicans Candida species (NAC), resistance was observed against flucytosine (16.04%), followed by fluconazole (14.81%), voriconazole (3.70%), and caspofungin (3.70%).

Conclusion: Non-albicans Candida spp. predominated over Candida albicans in causing bloodstream infections and were found to be more resistant to antifungals. Continuous surveillance is necessary to monitor changes in epidemiological and resistance patterns.

念珠菌病:印度北部一家三级保健医院的动态变化。
背景与目的:常规鉴定念珠菌种类和了解抗生素敏感性模式可以防止诊断延误,帮助临床医生选择适当的经验性治疗。本研究旨在鉴定和鉴定印度北部一家三级医院血液感染中分离的念珠菌,并评估其流行病学概况和抗生素敏感性模式。材料与方法:2019年1月至2021年5月在某三级医院微生物科采集血液样本进行培养,其中有念珠菌(spp.)生长的样本纳入本研究。念珠菌分离株最初采用常规技术进行鉴定。进一步鉴定和抗真菌药敏试验采用Vitek 2紧凑型自动化系统。采用SPSS软件(25.0版)进行数据分析。结果:116份血样中检出念珠菌,男性占60.92%。分离株以0 ~ 1月龄新生儿最多(43.10%),其次为婴幼儿(16.38%)和1 ~ 17岁儿童(16.38%)。只有6.89%的分离株来自18岁以上的成年人。最常见的菌种为热带念珠菌(26.72%),其次为外膜念珠菌(19.83%)、白色念珠菌(17.24%)、假丝酵母菌(14.66%)、famata念珠菌(9.48%)和krusei念珠菌(9.48%)。其他分离种包括路西念珠菌、球形念珠菌和隐匿念珠菌。116株分离株中,101株进行了Vitek 2药敏试验。总体而言,21.78%(22/101)的念珠菌分离株为耐药/中间菌株。白色念珠菌仅对伏立康唑(20%)和氟康唑(5%)耐药;非白色念珠菌(NAC)对氟胞嘧啶(16.04%)耐药,其次是氟康唑(14.81%)、伏立康唑(3.70%)和卡泊芬金(3.70%)。结论:非白色念珠菌在引起血液感染方面优于白色念珠菌,且对抗真菌药物的耐药性更强。为监测流行病学和耐药性模式的变化,需要持续监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Medical Mycology
Current Medical Mycology Medicine-Infectious Diseases
CiteScore
2.10
自引率
0.00%
发文量
16
审稿时长
4 weeks
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