Immediate Effect in the Retina and Choroid after 650 nm Low-Level Red Light Therapy in Children.

IF 2 4区医学 Q2 OPHTHALMOLOGY

Ophthalmic Research Pub Date : 2023-01-01 Epub Date: 2022-10-31 DOI:10.1159/000527787

Weiming Yang, Feng Lin, Meiyan Li, Ruoyan Wei, Jiaqi Zhou, Xingtao Zhou

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引用次数: 4

Abstract

Introduction: The objective of this study was to investigate the changes in the retina and choroid of children after 650 nm low-level red light therapy (LLRLT).

Methods: In this prospective study, 25 subjects in the Shanghai Eye and ENT Hospital of Fudan University were included from August 2021 to September 2021. One eye was randomly selected to receive LLRLT for 3 min. Swept-source optical coherence tomography (OCT) and OCT angiography were used to measure retinal fovea perfusion density (RFPD), retinal fovea thickness (RFT), choroidal fovea blood flow (CFBF), and choroidal fovea thickness (CFT) before LLRLT, 5 min and 1 h after LLRLT. Baseline characteristics between LLRLT and non-LLRLT eyes were compared. Changes in the retinal and choroidal parameters were analyzed by ANCOVA models. SAS software was used for data analysis. The difference was considered statistically significant if p < 0.05.

Results: There was no difference in baseline characteristics between LLRLT eyes and non-LLRLT eyes. The RFPD in LLRLT eyes significantly increased 5 min after LLRLT, and the increment was 1.70 ± 0.83% (p = 0.0389). The RFPD significantly decreased from 5 min to 1 h after LLRLT with a mean of -2.62 ± 0.86% decrement (p = 0.0031). The RFPD levels returned to baseline at 1 h after LLRLT (p = 0.8646). However, compared with insignificant RFPD changes in non-LLRLT eyes, there was no significant difference in RFPD changes at any sampling point. No significant changes in RFT, CFBF, and CFT were found in LLRLT eyes at each sampling point.

Conclusion: Although 3 min of LLRLT has no effect on the choroid, it may cause a short-term transient increase in RFPD. It will provide theoretical support for the role of LLRLT in myopia control.

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儿童接受 650 纳米低强度红光治疗后视网膜和脉络膜的立竿见影效果

导言本研究旨在探讨650纳米低强度红光治疗（LLRLT）后儿童视网膜和脉络膜的变化：在这项前瞻性研究中，25 名受试者于 2021 年 8 月至 2021 年 9 月在复旦大学附属上海眼耳鼻喉科医院接受治疗。随机选取一只眼接受 LLRLT 治疗 3 分钟。采用扫源光学相干断层扫描（OCT）和OCT血管造影测量LLRLT前、LLRLT后5分钟和1小时的视网膜眼窝灌注密度（RFPD）、视网膜眼窝厚度（RFT）、脉络膜眼窝血流（CFBF）和脉络膜眼窝厚度（CFT）。比较了 LLRLT 和非 LLRLT 眼睛的基线特征。视网膜和脉络膜参数的变化通过方差分析模型进行分析。数据分析采用 SAS 软件。如果 P < 0.05，则认为差异具有统计学意义：结果：LLRLT 眼睛和非 LLRLT 眼睛的基线特征没有差异。LLRLT 5 分钟后，LLRLT 眼睛的 RFPD 明显增加，增量为 1.70 ± 0.83% (p = 0.0389)。LLRLT 后 5 分钟至 1 小时，RFPD 明显下降，平均降幅为 -2.62 ± 0.86% (p = 0.0031)。LLRLT 1 小时后，RFPD 水平恢复到基线（p = 0.8646）。然而，与非 LLRLT 眼睛中不显著的 RFPD 变化相比，任何采样点的 RFPD 变化均无显著差异。在每个取样点，LLRLT 眼睛的 RFT、CFBF 和 CFT 均无明显变化：结论：虽然 3 分钟的 LLRLT 对脉络膜没有影响，但它可能会导致 RFPD 的短期短暂增加。这将为 LLRLT 在近视控制中的作用提供理论支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic Research 医学-眼科学

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.

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