Postmortem Diffusion-Weighted Magnetic Resonance Imaging of the Brain in Perinatal Death: An Animal Control Study to Detect the Influence of Postmortem Interval.

Q2 Medicine

Topics in Magnetic Resonance Imaging Pub Date : 2022-10-01 DOI:10.1097/RMR.0000000000000299

Maud P M Tijssen, Simon G F Robben, Willemijn M Klein, Paul A M Hofman

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引用次数: 0

Abstract

Objectives: Diffusion-weighted imaging may be useful as part of a postmortem magnetic resonance imaging protocol. However, apart from the effect of temperature on apparent diffusion coefficient (ADC), normal postmortem ADC changes can influence the interpretation. Therefore, this study was conducted to evaluate the correlation between normal ADC changes and postmortem intervals (PMIs) and develop a reference standard for postmortem changes after temperature correction.

Materials and methods: Six premature lambs were scanned at different PMIs. ADC values were measured at different parenchymal locations. Correlation and linear regression between ADC values and PMI were analyzed for all locations, both uncorrected and corrected for temperature.

Results: All locations showed a significant negative correlation between the PMI and ADC value, with (R2 = 0.581-0.837, P < 0.001) and without (R2 = 0.183-0.555, P < 0.001-0.018) temperature correction.

Conclusions: The postmortem interval is negatively correlated with ADC values in the brain. A correlation coefficient for the PMI can be calculated after temperature correction to predict ADC changes. However, further research is required to evaluate its clinical application in humans.

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围生儿死亡时脑弥散加权磁共振成像:一项检测死后间隔影响的动物对照研究。

目的:弥散加权成像作为死后磁共振成像方案的一部分可能是有用的。然而，除了温度对表观扩散系数(ADC)的影响外，正常的死后ADC变化也会影响解释。因此，本研究旨在评估正常ADC变化与死后时间间隔(PMIs)的相关性，并为温度校正后的死后变化制定参考标准。材料与方法:对6只早产儿羔羊进行不同pmi扫描。在不同实质位置测量ADC值。分析了所有地点的ADC值与PMI之间的相关性和线性回归，包括未校正和校正温度。结果:各部位PMI与ADC值呈显著负相关，存在(R2 = 0.581 ~ 0.837, P < 0.001)温度校正，无(R2 = 0.183 ~ 0.555, P < 0.001 ~ 0.018)温度校正。结论:死亡时间与脑内ADC值呈负相关。温度校正后可以计算PMI的相关系数来预测ADC的变化。然而，还需要进一步的研究来评估其在人体中的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Topics in Magnetic Resonance Imaging Medicine-Medicine (all)

CiteScore

5.50

自引率

0.00%

发文量

期刊介绍： Topics in Magnetic Resonance Imaging is a leading information resource for professionals in the MRI community. This publication supplies authoritative, up-to-the-minute coverage of technical advances in this evolving field as well as practical, hands-on guidance from leading experts. Six times a year, TMRI focuses on a single timely topic of interest to radiologists. These topical issues present a variety of perspectives from top radiological authorities to provide an in-depth understanding of how MRI is being used in each area.