Nikeya L Macioce-Tisdale, Alan Ashbaugh, Keeley Hendrix, Margaret S Collins, Aleksey Porollo, Melanie T Cushion
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引用次数: 1
Abstract
Many preclinical studies of infectious diseases have neglected experimental designs that evaluate potential differences related to sex with a concomitant over-reliance on male model systems. Hence, the NIH implemented a monitoring system for sex inclusion in preclinical studies.
Methods: Per this mandate, we examined the lung burdens of Pneumocystis murina infection in three mouse strains in both male and female animals at early, mid, and late time points.
Results: Females in each strain had higher infection burdens compared to males at the later time points.
Conclusion: Females should be included in experimental models studying Pneumocystis spp.
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