The effect of Zingiber Officinale Extract on Preventing Demyelination of Corpus Callosum in a Rat Model of Multiple Sclerosis

Q2 Biochemistry, Genetics and Molecular Biology

Iranian Biomedical Journal Pub Date : 2022-07-01 DOI:10.52547/ibj.2979

Valiollah Moradi, Ebrahim Esfandiary, Mustafa Ghanadian, Nazem Ghasemi, Bahman Rashidi

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Abstract

Background: Multiple sclerosis (MS) is the most prevalent neurological disability of young adults. Anti-inflammatory drugs have relative effects on MS. The anti-inflammatory and antioxidative effects of Zingiber officinale (ginger) have been proven in some experimental and clinical investigations. The aim of this study was to evaluate the effects of ginger extract on preventing myelin degradation in a rat model of MS.

Methods: Forty nine male Wistar rats were used in this study and divided into four control groups: the normal group, cuprizone-induced group, sham group (cuprizone [CPZ] + sodium carboxymethyl cellulose [NaCMC]), standard control group (fingolimod + cuprizone), including three experimental groups of CPZ, each receiving three different doses of ginger extract: 150, 300, and 600mg/kg /kg/day.

Results: Ginger extract of 600 mg/kg prevented corpus callosum from demyelination; however, a significant difference was observed in the fingolimod group (p < 0.05). Difference in the CPZ group was quite significant (p < 0.05).

Conclusion: Treatment with ginger inhibited demyelination and alleviated remyelination of corpus callosum in rats. Therefore, it could serve as a therapeutic agent in the MS.

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银杏叶提取物对预防多发性硬化大鼠模型胼胝体脱髓鞘的影响

背景：多发性硬化症（MS）是青壮年中最常见的神经系统残疾。抗炎药物对多发性硬化症有相对的疗效。生姜的抗炎和抗氧化作用已在一些实验和临床研究中得到证实。本研究旨在评估生姜提取物在多发性硬化症大鼠模型中防止髓鞘降解的效果：方法：本研究采用49只雄性Wistar大鼠，分为4个对照组：正常组、铜试剂诱导组、假对照组（铜试剂[CPZ]+羧甲基纤维素钠[NaCMC]）、标准对照组（芬戈莫德+铜试剂），包括3个铜试剂实验组，每组接受3种不同剂量的生姜提取物：150、300和600毫克/千克/天：600毫克/千克的生姜提取物可防止胼胝体脱髓鞘，但芬戈莫德组的差异显著（P < 0.05）。CPZ组的差异相当显著（P < 0.05）：结论：生姜治疗可抑制大鼠胼胝体脱髓鞘并减轻其再髓鞘化。因此，生姜可作为多发性硬化症的治疗药物。

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