The WHOQOL-BREF instrument: Psychometric evaluation of the Greek version in patients with advanced cancer and pain and associations with psychological distress.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-01 DOI:10.1017/S1478951522001055

Vassiliki Siafaka, Dimitris Mavridis, Orestis Tsonis, Eleftheria Tzamakou, Christos Christogiannis, Louiza Tefa, Eleni Arnaoutoglou, Petros Tzimas, George Pentheroudakis

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引用次数: 0

Abstract

Objectives: Assessment of the psychometric characteristics of the Greek version of the brief World Health Organization Quality of Life Instrument (WHOQOL-BREF) in patients with advanced cancer and pain, and exploration of the association between psychological distress and quality of life (QoL).

Method: The sample consisted of 145 patients with advanced cancer and pain who completed the WHOQOL-BREF, the Symptom Checklist-90 (SCL-90), and the Pain Visual Analogue Scale (VAS). In analysis, the following methods were used: Cronbach's alpha, Item Response Theory (IRT), polychoric, Pearson and polyserial correlation, t-test, and Linear regression.

Results: The internal consistency was high for all domains of the WHOQOL-BREF (Cronbach's α ≥ 0.731). Similarly, with the exception of three items, the WHOQOL-BREF items has large discrimination parameters suggesting that they have a high ability in differentiating subjects. On SCL-90, the three dimensions with the highest scores were Depression, Somatization, and Anxiety. The overall score for psychological distress, the Global Severity Index (GSI), showed significant negative association with all the WHOQOL-BREF factor scores (Physical Health: B = -1.488, p < 0.001, Psychological Health: B = -1.688, p < 0.001, Social Relationships: B = -0.910, p < 0.001, Environment: B = -1.064, p < 0.001). Male gender was associated with lower scores for Social Relationships (B = -0.358, p = 0.007) and Environment (B = -0.293, p = 0.026).

Significance of results: The Greek version of the WHOQOL-BREF showed good psychometric properties in patients with advanced cancer and can be used as a reliable instrument in clinical practice. The level of psychological distress can be considered a determinant of QoL in patients with advanced cancer and pain, independently of pain intensity or other clinical characteristics. In cancer, the disease process can activate multiple physiological and psychological mechanisms that lead to a wide range of symptoms of psychological distress. To improve their QoL, psychological intervention focused on the identification and alleviation of psychological distress in patients with advanced cancer, and help in finding meaning in their experience, should be provided.

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WHOQOL-BREF 工具：对希腊语版晚期癌症和疼痛患者的心理计量学评估以及与心理困扰的关联。

研究目的评估希腊版世界卫生组织生活质量简表（WHOQOL-BREF）在晚期癌症疼痛患者中的心理测量特征，并探讨心理困扰与生活质量（QoL）之间的关联：样本包括 145 名晚期癌症疼痛患者，他们填写了 WHOQOL-BREF、症状检查表-90（SCL-90）和疼痛视觉模拟量表（VAS）。分析中使用了以下方法：Cronbach's alpha、项目反应理论（IRT）、多序列相关、皮尔逊相关和多序列相关、t 检验和线性回归：结果：WHOQOL-BREF 所有领域的内部一致性都很高（Cronbach's α ≥ 0.731）。同样，除三个项目外，WHOQOL-BREF 项目的区分度参数较大，表明它们具有较高的区分能力。在 SCL-90 中，得分最高的三个维度是抑郁、躯体化和焦虑。心理困扰的总分，即全球严重程度指数（GSI），与所有 WHOQOL-BREF 因子得分均呈显著负相关（身体健康：B = -1.488，p = 0.5）：B = -1.488, p < 0.001，心理健康：B=-1.688，p < 0.001，社会关系：B = -0.910，p < 0.001，环境：B=-1.064，p＜0.001）。男性在社会关系（B = -0.358，p = 0.007）和环境（B = -0.293，p = 0.026）方面得分较低：希腊语版 WHOQOL-BREF 在晚期癌症患者中显示出良好的心理测量特性，可作为可靠的工具用于临床实践。晚期癌症疼痛患者的心理困扰程度可被视为影响生活质量的一个决定因素，与疼痛强度或其他临床特征无关。在癌症患者中，疾病过程会激活多种生理和心理机制，从而导致各种心理困扰症状。为改善晚期癌症患者的生活质量，应提供心理干预，重点是识别和减轻晚期癌症患者的心理困扰，并帮助他们从自己的经历中寻找意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.