Enhanced Well-Being Associated with Thyrotoxicosis: A Neglected Effect of Thyroid Hormones?

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM

International Journal of Endocrinology and Metabolism Pub Date : 2022-05-29 eCollection Date: 2022-04-01 DOI:10.5812/ijem-127230

Petros Perros, Laszlo Hegedus

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Abstract

Context: Thyrotoxicosis may be associated with a better sense of well-being than in the euthyroid state, though this is not widely recognised.

Evidence acquisition: A comprehensive literature search in PubMed and Google Scholar, was performed to identify studies investigating factors influencing well-being, mood, and psychological features associated with elevated thyroid hormones.

Results: Enhanced well-being associated with thyrotoxicosis has been described, although the evidence is observational and anecdotal.

Conclusions: Enhanced well-being associated with thyrotoxicosis is probably experienced in a minority of patients and may explain why some seek overtreatment with thyroid hormones and report significant improvement on larger than physiological thyroid hormone replacement regimens. It may also explain why some patients with hyperthyroidism (usually due to Graves' disease) are reluctant to adhere to anti-thyroid medication.

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增强幸福感与甲状腺毒症相关:甲状腺激素的忽视作用?

背景:甲状腺毒症患者可能比甲状腺功能正常的人有更好的幸福感，尽管这一点尚未得到广泛认可。证据获取:在PubMed和Google Scholar中进行了全面的文献检索，以确定与甲状腺激素升高相关的影响幸福感、情绪和心理特征的因素。结果:虽然证据是观察性和轶事性的，但已经描述了甲状腺毒症患者的幸福感增强。结论:与甲状腺毒症相关的幸福感增强可能在少数患者中出现，这可能解释了为什么有些患者寻求甲状腺激素的过度治疗，并报告比生理性甲状腺激素替代方案有显著改善。这也可以解释为什么一些甲亢患者(通常是由于格雷夫斯病)不愿意坚持抗甲状腺药物治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.