Medical cannabis and cannabidiol: A new harvest for Malawi.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-06-01 DOI:10.4314/mmj.v34i2.10

Gama Bandawe

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引用次数: 1

Abstract

In February 2020 parliament passed the Cannabis Regulation Bill (2020) which regulates the cultivation and production of industrial hemp and medical cannabis. The country will only fully benefit from this development if the medical and scientific community can take the lead in enabling the country to exploit the plant's potential to help address some of our economic and public health challenges. This special communication provides some basic information on cannabis and discusses its history and medical uses. Cannabidiol (CBD) has emerged as one of the most important cannabis-derived phytochemicals and has formed the basis for the growth of the medical cannabis industry. The scientific data on the mechanisms of the effects of CBD on the human neuroendocrine-immune network is reviewed and the first effective cannabis-based FDA-approved treatment for epilepsy discussed. Some clinical research that is being done on the antipsychotic and neuroprotective properties of CBD is also reviewed. A case is made for the potential of CBD as a neuroprotective adjunctive therapy for the prevention of neuropsychological sequelae associated with complicated malaria. The safety profile of CBD is reviewed and finally, the potential importance of the re-medicalization of cannabis-based therapies for the broader field of phytomedicine is pointed out.

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医用大麻和大麻二酚:马拉维的新收获。

2020年2月，议会通过了《大麻监管法案》（2020年），该法案对工业大麻和医用大麻的种植和生产进行了监管。只有医学和科学界能够率先使该国能够利用该工厂的潜力，帮助解决我们的一些经济和公共卫生挑战，该国才能从这一发展中充分受益。这份特别来文提供了关于大麻的一些基本信息，并讨论了大麻的历史和医疗用途。大麻二酚（CBD）已成为最重要的大麻衍生植物化学物质之一，并成为医用大麻行业发展的基础。综述了CBD对人类神经内分泌免疫网络影响机制的科学数据，并讨论了美国食品药品监督管理局批准的第一种有效的大麻类癫痫治疗方法。对CBD抗精神病和神经保护特性的一些临床研究也进行了综述。CBD作为一种神经保护辅助疗法，有可能预防与复杂疟疾相关的神经心理后遗症。综述了CBD的安全性，最后指出了大麻疗法在更广泛的植物医学领域的潜在重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.